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Platelet activation and signaling in thrombus formation.
Blood
January 2025
Medical University of Vienna, Vienna, Austria.
In thrombosis and hemostasis, the formation of a platelet-fibrin thrombus or clot is a highly controlled process that varies, depending on the pathological context. Major signaling pathways in platelets are well established. However, studies with genetically modified mice have identified the contribution of hundreds of additional platelet-expressed proteins in arterial thrombus formation and bleeding.
View Article and Find Full Text PDF14-3-3 promotes sarcolemmal expression of cardiac Ca1.2 and nucleates isoproterenol-triggered channel superclustering.
Proc Natl Acad Sci U S A
February 2025
Department of Physiology and Membrane Biology, University of California Davis, Davis, CA 95616.
The L-type Ca channel (Ca1.2) is essential for cardiac excitation-contraction coupling. To contribute to the inward Ca flux that drives Ca-induced-Ca-release, Ca1.
View Article and Find Full Text PDFFatty acid metabolism and the oxidative stress response support bacterial predation.
Proc Natl Acad Sci U S A
February 2025
Aix-Marseille Université-CNRS UMR 7283, Institut de Microbiologie de la Méditerranée and Turing Center for Living Systems, Marseille 13009, France.
Despite growing awareness of their importance in soil ecology, the genetic and physiological traits of bacterial predators are still relatively poorly understood. In the course of a predator evolution experiment, we identified a class of genotypes leading to enhanced predation against diverse species. RNA-seq analysis demonstrated that this phenotype is linked to the constitutive activation of a predation-specific program.
View Article and Find Full Text PDFStrigolactones regulate Bambusa multiplex sheath senescence by promoting chlorophyll degradation.
Tree Physiol
January 2025
State Key Laboratory of Tree Genetics and Breeding, Co-Innovation Center for Sustainable Forestry in Southern China, Bamboo Research Institute, Key Lab of National Forestry and Grassland Administration on Subtropical Forest Biodiversity Conservation, School of Life Sciences, Nanjing Forestry University, Nanjing 210037, China.
Culm sheaths are capable of photosynthesis and are an important class of non-leaf organs in bamboo plants. The source-sink interaction mechanism has been found to play an important role in the interaction between culm sheaths and internodes in Bambusa multiplex. Research on the regulatory mechanisms of culm sheath senescence is important for the study of internode growth, but reports in this regard are limited.
View Article and Find Full Text PDFIntraspecific Variation and Recent Loss of Ancient, Conserved Effector Genes in the Sudden Oak Death Pathogen .
Mol Plant Microbe Interact
January 2025
USDA ARS, Horticultural Crops Research Laboratory, 3420 NW Orchard Ave., Corvallis, Oregon, United States, 97330;
Members of the genus are responsible for many important diseases in agricultural and natural ecosystems. causes devastating diseases of oak, and tanoak stands in US forests and larch in the UK. The four evolutionary lineages involved express different virulence phenotypes on plant hosts, and characterization of gene content is foundational to understanding the basis for these differences.
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