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Pharmacokinetics, Pharmacodynamics and Bioavailability of ACM-001.1 (S-Pindolol Benzoate) in Healthy Volunteers.
J Cachexia Sarcopenia Muscle
February 2025
Quotient Sciences, Nottingham, UK.
Background: S-pindolol has metabolic effects of potential benefit in cancer cachexia: reduced catabolism through nonselective β-blockade; increased anabolism through partial β2 receptor agonism; and increased appetite and reduced fatigue through central 5-hydroxytryptamine/serotonin receptor activity. A Phase 2a clinical trial demonstrated that S-pindolol can reverse weight loss and improve fat-free mass in patients with cancer-related weight loss. A comparative phase I bioavailability study of S-pindolol and racemic pindolol was performed to support the development of S-pindolol in cancer cachexia.
View Article and Find Full Text PDFCognitive Effects of Three β-Adrenoceptor Acting Drugs in Healthy Volunteers and Patients with Parkinson's Disease.
J Parkinsons Dis
September 2024
CuraSen Therapeutics, San Carlos, CA, USA.
Article Synopsis
- The study investigates the effects of β-adrenoceptor acting drugs on cognitive function in healthy volunteers and Parkinson's disease patients.
- Clenbuterol showed improvements in cognitive tasks and pupil reactions, while pindolol had negative effects on performance.
- The findings suggest that clenbuterol might enhance cognitive abilities via stimulation of β2-adrenoceptors in the central nervous system.
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