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Antimicrobial and anti-endotoxin activity of N-acetylcysteine, calcium hydroxide and their combination against and lipopolysaccharides.
PeerJ
October 2024
Department of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, Campus of São José dos Campos, São Paulo State University (ICT-Unesp), São José dos Campos, São Paulo, Brazil.
Background: The management of endodontic infections is a complex challenge, mainly due to the involvement of diverse microorganisms and their by-products. This study aimed to evaluate the efficacy of N-acetylcysteine (NAC), calcium hydroxide (Ca(OH)), and their combined application as intracanal medications in combating , , and lipopolysaccharides (LPS) from .
Methods: A total of 60 single-rooted human teeth were carefully selected and divided into six groups.
Development of Nontoxic Peptides for Lipopolysaccharide Neutralization and Sepsis Treatment.
ACS Pharmacol Transl Sci
June 2024
Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Host defense peptides (HDPs), also named antimicrobial peptides (AMPs), are increasingly being recognized for serving multiple functions in protecting the host from infection and disease. Previous studies have shown that various HDPs can also neutralize lipopolysaccharide (LPS, endotoxin), as well as lipoteichoic acid (LTA), inducing macrophage activation. However, antimicrobial activity is usually accompanied by systemic toxicity which makes it difficult to use HDPs as antiendotoxin agents.
View Article and Find Full Text PDFInfluence of PepF peptidase and sporulation on microcin J25 production in .
Microbiol Spectr
July 2024
College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Unlabelled: The lasso peptide microcin J25 (MccJ25) possesses strong antibacterial properties and is considered a potential effective component of bacterial disease treatment drugs and safe food preservatives. Although MccJ25 can be heterologously expressed in as we have previously reported, its regulation and accumulation are yet to be understood. Here, we investigated the expression level and stability of MccJ25 in strains with disruption in peptidase genes , and .
View Article and Find Full Text PDFEffects of total saikosaponins on CYP3A4 and CYP1A2 in HepaRG cells.
Exp Ther Med
May 2024
The Key Laboratory of Clinical Pharmacy of Zunyi City, Zunyi Medical University, Zunyi, Guizhou 563006, P.R. China.
Total saikosaponins (TSS) form a group of chemically and biologically active components that can be extracted from Bupleurum, with reported antidepressive, anti-inflammatory, antiviral, antiendotoxin, antitumor, anti-pulmonary fibrosis and anti-gastric ulcer effects. Bupleurum or TSS is frequently utilized in clinical practice alongside other medications (such as entecavir, lamivudine, compound paracetamol and amantadine hydrochloride capsules), leading to an increased risk of drug-drug interactions. The cytochrome P450 (CYP) family serves a critical role in the metabolism of numerous essential drugs (such as tamoxifen, ibuprofen and phenytoin), where the majority of drug interactions involve CYP-mediated metabolism.
View Article and Find Full Text PDFHydrocarbon stapled temporin-L analogue as potential antibacterial and antiendotoxin agents with enhanced protease stability.
Bioorg Chem
April 2024
Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard (Deemed to be University), New Delhi 110062, India. Electronic address:
Antimicrobial resistance (AMR) is a serious global concern and a huge burden on the healthcare system. Antimicrobial peptides (AMPs) are considered as a solution of AMR due to their membrane-lytic and intracellular mode of action and therefore resistance development against AMPs is less frequent. One such AMPs, temporin-L (TL) is a 13-mer peptide reported as a potent and broad-spectrum antibacterial agent with significant immunomodulatory activity.
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