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Memory is incorporated into the brain as physicochemical changes to engram cells. These are neuronal populations that form complex neuroanatomical circuits, are modified by experiences to store information, and allow for memory recall. At the molecular level, learning modifies synaptic communication to rewire engram circuits, a mechanism known as synaptic plasticity.
View Article and Find Full Text PDFMicrobial community of Nongxiangxing daqu during storage: microbial succession, assembly mechanisms and metabolic functions.
J Sci Food Agric
January 2025
College of Biomass Science and Engineering, Sichuan University, Chengdu, China.
Background: The storage process of Nongxiangxing daqu is closely related to the quality of the daqu. The role of storage in daqu manufacture remains unclear, and most actual production relies on previous production experience.
Results: With the extension of daqu storage over a period of time, saccharifying activity, liquefying activity, fermenting activity, and esterifying activity reached a peak when stored for 3 to 4 months.
Gene content of seawater microbes is a strong predictor of water chemistry across the Great Barrier Reef.
Microbiome
January 2025
Australian Institute of Marine Science, PMB no3 Townsville MC, Townsville, QLD, 4810, Australia.
Background: Seawater microbes (bacteria and archaea) play essential roles in coral reefs by facilitating nutrient cycling, energy transfer, and overall reef ecosystem functioning. However, environmental disturbances such as degraded water quality and marine heatwaves, can impact these vital functions as seawater microbial communities experience notable shifts in composition and function when exposed to stressors. This sensitivity highlights the potential of seawater microbes to be used as indicators of reef health.
View Article and Find Full Text PDFPhysicochemical Properties of Curen® Filaments Versus Nylon Filaments in Toothbrush Bristles: An In Vitro Study.
Cureus
December 2024
Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad, IND.
Background Toothbrush manufacturers commonly use bristle materials such as nylon, polybutylene terephthalate, polypropylene, polyethylene terephthalate, boar hair, bamboo, carbon fiber, silicone, polylactic acid, or their modifications such as Curen. Nylon filaments have long been demonstrated to be durable and are widely used, but not much is known regarding the performance of Curen filaments compared to nylon filaments. This in vitro study compared the stiffness, abrasion potential, abrasion resistance, and bristle surface changes of Curen and nylon filaments.
View Article and Find Full Text PDFThe development of paliperidone nanocrystals for the treatment of schizophrenia.
Prog Biomed Eng (Bristol)
November 2024
State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, People's Republic of China.
Schizophrenia is a complex and chronic psychiatric disorder that significantly impacts patients' quality of life. Ranking 12th among 310 diseases and injuries that result in disability, the number of patients suffering from schizophrenia continues to rise, emphasizing the urgent need for developing effective treatments. Despite the availability of effective antipsychotic drugs, over 80% of patients taking oral antipsychotics experience relapses, primarily caused by non-adherence as the high dosing frequency is required.
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