Download full-text PDF

Source
http://dx.doi.org/10.1192/bjp.101.424.538DOI Listing

Publication Analysis

Top Keywords

adrenochrome schizophrenia
4
schizophrenia investigation
4
investigation deductions
4
deductions hypothesis
4
adrenochrome
1
investigation
1
deductions
1
hypothesis
1

Similar Publications

Niacin-respondent subset of schizophrenia – a therapeutic review.

Eur Rev Med Pharmacol Sci

November 2015

Department of Pharmacy, Liaocheng People's Hospital, Liaocheng, Shandong, P.R. China.

It is well known that niacin deficiency manifests with several psychiatric manifestations. Also historically evidence has accumulated that niacin augmentation can be used for treatment of schizophrenia. However, the etiopathological associations between niacin deficiency and schizophrenia as well as the mechanism of action of niacin in its treatment.

View Article and Find Full Text PDF

Working in a psychiatrically innovative environment created by the Government of Saskatchewan, Canada, Abram Hoffer and Humphry F. Osmond enunciated the adrenochrome hypothesis for the biogenesis of schizophrenia in 1952, slightly later proposing and, apparently, demonstrating, in a double-blind study, that the symptoms of the illness could be reversed by administering large doses of niacin. After placing the hypothesis within its ideological framework, the author describes its emergence and elaboration and discusses the empirical evidence brought against it.

View Article and Find Full Text PDF

Schizophrenia and cancer: the adrenochrome balanced morphism.

Med Hypotheses

October 2004

Department of Geography, University of Victoria, P.O. Box 3050, Victoria, BC, Canada V8W 3P5.

Cancer might be expected to be more common amongst schizophrenics than the general population. They frequently live in selenium deficient regions, have seriously compromised antioxidant defense systems and chain-smoke. The available literature on the cancer-schizoprenia relationship in patients from England, Wales, Ireland, Denmark, USA and Japan, however, strongly suggests that the reverse is true.

View Article and Find Full Text PDF

The adrenochrome hypothesis of schizophrenia revisited.

Neurotox Res

March 2002

Department of Psychology, Center for Brain and Cognition, University of California at San Diego, La Jolla, CA 92093-0109, USA; and Department of Neuropsychiatry, Institute of Neurology, Queen Square, London, UK.

This paper reviews the current status of the adrenochrome theory of schizophrenia. An account is first given of all the experiments in which adrenochrome was reported to induce psychotomimetic effects in normal volunteers. Then the evidence is presented that adrenochrome may actually occur in the brain as a metabolite of adrenaline in the C2 group of adrenergic neurons in the medulla, together with an account of current ideas of the function of these neurons in higher limbic functions.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!