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Riboflavin as a potential new therapeutic agent for perinatal encephalopathies caused by cerebral oxygen deprivation.
Nutr Neurosci
October 2024
Graduate Program in Neuropsychiatry and Behavioral Sciences, Center for Medical Sciences, Federal University of Pernambuco, Recife, Brazil.
: This letter to the editor presents suggestions for the therapeutic use of riboflavin in perinatal brain lesions caused by oxygen deprivation.: Clinical and preclinical studies using riboflavin conjugated with other components for the treatment of cerebral oxygen deprivation were included in the discussion.: Oxygen deprivation is predisposed by anoxia, hypoxia, or ischemia and causes severe early central damage, including sensorimotor impairment.
View Article and Find Full Text PDFNovel platform for engineering stable and effective vaccines against botulinum neurotoxins A, B and E.
Front Immunol
September 2024
School of Biotechnology, Dublin City University, Dublin, Ireland.
Botulinum neurotoxin (BoNT), produced by , is the most toxic protein known, capable of causing severe paralysis and posing a significant bioterrorism threat due to its extreme lethality even in minute quantities. Despite this, there are currently no FDA-approved vaccines for widespread public use. To address this urgent need, we have developed an innovative vaccine platform by fusing the neuronal binding domain of BoNT/E (Hc/E) with core-streptavidin (CS), resulting in a stable CS-Hc/E vaccine.
View Article and Find Full Text PDFSevere Neonatal Jaundice (SNJ) causes long-term neurocognitive impairment, cerebral palsy, auditory neuropathy, deafness, or death. We developed a mathematical model for allo-hemodialysis as a potential blood purification method for the treatment of SNJ in term or near-term infants. With allo-hemodialysis (allo-HD), the neonate's blood flows through hollow fibers of a miniature 0.
View Article and Find Full Text PDFTongue exercise ameliorates structural and functional upper airway deficits in a rodent model of hypoglossal motor neuron loss.
Front Neurol
September 2024
Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, United States.
Introduction: Tongue weakness and atrophy can lead to deficits in the vital functions of breathing and swallowing in patients with motor neuron diseases (MNDs; e.g., amyotrophic lateral sclerosis (ALS) and pseudobulbar palsy), often resulting in aspiration pneumonia, respiratory failure, and death.
View Article and Find Full Text PDFA perspective on the novel pentavalent Men5CV (NmCV-5) meningitis vaccine and Nigeria's pioneering rollout campaign.
Infez Med
September 2024
Community and Clinical Research Division, First On-Call Initiative, Port Harcourt, Nigeria.
The burden of meningitis poses great challenges for neurology and global health, manifesting with a range of symptoms from mild fever and headaches, to severe long term complications such as paralysis and cognitive impairment.. Unfortunately, those living in endemic regions, especially survivors, are often confronted with the harsh reality of reduced quality of life as measured by disability-adjusted life years.
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