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The Effect of PEGylation on Drugs' Pharmacokinetic Parameters; from Absorption to Excretion.
Curr Drug Deliv
May 2024
Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Until the drugs enter humans life, they may face problems in transportation, drug delivery, and metabolism. These problems can cause reducing drug's therapeutic effect and even increase its side effects. Together, these cases can reduce the patient's compliance with the treatment and complicate the treatment process.
View Article and Find Full Text PDF[Synthesis and CNS-activity of spirocyclic pethidine and prodine analogs].
Arch Pharm (Weinheim)
September 1993
Institut für Pharmazie und Lebensmittelchemie, Universität München.
The bromoacetals 5a and 5b react with n-butyllithium and the piperidone 7 to yield the hydroxyacetals 8b and 8c, respectively. Cyclization of 8b and 8c followed by acid hydrolysis affords the spirocyclic hemiacetals 10b and 10c which are oxidized by PCC to give the spirocyclic prodine analogues 4b and 4c. The corresponding spirocyclic pethidine derivative 2 is prepared by alkylation of the 2-benzopyran-3-one 16 with N-Lost (17).
View Article and Find Full Text PDFObstetrical medication and the newborn infant. II: The influence of meperidine (pethidine) on visual behaviour.
Dev Med Child Neurol
March 1992
Department of Psychology, Memorial University of Newfoundland, St. John's.
The visual fixation of two groups of healthy newborn infants was tested at a mean age of three days. Mothers of the infants in one group received a single dose of meperidine (pethidine) during labour and delivery; those in the second group received no medication. Unlike infants of mothers who received a single dose of alphaprodine hydrochloride in a previous study, there were no differences between the groups in the present study.
View Article and Find Full Text PDFGABAmimetics diminish antinociception of meperidine under conditions which enhance other opioid mu-agonists.
Arch Int Pharmacodyn Ther
December 1990
Department of Pharmacology, Dental School, University of Maryland, Baltimore 21201.
This study investigated the effects of pretreatment with muscimol (GABA-agonist) or diazepam (indirect GABAmimetic) on i.v. meperidine, fentanyl, alphaprodine and morphine, using rabbit tooth pulp and mouse hot plate assays.
View Article and Find Full Text PDFSinusoidal fetal heart rate.
J Perinat Med
August 1988
Department of Obstetrics and Gynecology, University of Montreal, Canada.
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