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Optimization of central carbon metabolism by Warburg effect of human cancer cell improves triterpenes biosynthesis in yeast.
Adv Biotechnol (Singap)
October 2023
Institute of Medical Plant Physiology and Ecology, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Optimizing central carbon metabolism (CCM) represents an attractive and challenging strategy to improve the biosynthesis of valuable chemicals due to the complex regulation of the CCM in yeast. In this study, we triggered the similar Warburg effect of cancer cells in yeast strains by introducing the human hypoxia-inducible factor-1 (HIF-1) complex, which regulated the expression of numerous enzymes involved in CCM and redirected the metabolic flux from glycolysis to tricarboxylic acid cycle. This redirection promoted the production of squalene to a 2.
View Article and Find Full Text PDFIdentifying metabolomic mediators of the physical activity and colorectal cancer relationship.
Cancer Epidemiol Biomarkers Prev
January 2025
University of Bristol, Bristol, United Kingdom.
Background: Current evidence suggests higher physical activity (PA) levels are associated with a reduced risk of colorectal cancer (CRC). However, the mediating role of the circulating metabolome in this relationship remains unclear.
Methods: Targeted metabolomics data from 6,055 participants in the EPIC cohort were used to identify metabolites associated with PA and derive a metabolomic signature of PA levels.
Recurrence of skin and soft tissue infections: identifying risk factors and treatment strategies.
Curr Opin Infect Dis
January 2025
Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna.
Purpose Of Review: Recurrent skin and soft tissue infections (RSSTIs) are challenging for the clinicians due to morbidity and healthcare-related costs. Here, we review updates on risk factors and management.
Recent Findings: RSSTIs rates range between 7 and 45%.
Effects of educational interventions for community pharmacists on promoting human papillomavirus vaccination: A randomized double-blind parallel group comparison trial.
Vaccine X
January 2025
Shinagawa Pharmaceutical Association, 2-4-2 Nakanobu, Shinagawa-ku, Tokyo 142-0053, Japan.
Objective: Owing to persistent concerns about side effects, human papillomavirus (HPV) vaccination rates in Japan have remained low. Pharmacists are therefore encouraged to improve vaccination rates by providing accurate information. This study evaluated the impact of educational interventions on pharmacists' knowledge and willingness to recommend the HPV vaccine.
View Article and Find Full Text PDFSelf-reported dyspnea and interest in a respiratory muscle training program among callers to the New York State Quitline.
Tob Induc Dis
January 2025
Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, United States.
Introduction: Cigarette smoking is an important risk factor in the development of dyspnea. Programs designed to strengthen the respiratory muscles can improve dyspnea in people with or without lung disease. As a first step in understanding the feasibility of offering a respiratory muscle training (RMT) program to people who are seeking help to try to quit smoking, we asked callers who contacted the New York State Quitline about their dyspnea and potential interest in a home-based RMT program.
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