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Superior efficacy of combination antibiotic therapy versus monotherapy in a mouse model of Lyme disease.
Front Microbiol
November 2023
Division of Immunology, Tulane National Primate Research Center, Tulane University, Covington, LA, United States.
Lyme disease (LD) results from the most prevalent tick-borne infection in North America, with over 476,000 estimated cases annually. The disease is caused by which transmits through the bite of Ixodid ticks. Most cases treated soon after infection are resolved by a short course of oral antibiotics.
View Article and Find Full Text PDFProduction of antibiotic carbomycin from Streptomyces graminofaciens with high lipid content mutation.
Arch Microbiol
April 2021
Biological and Geological Sciences Department, Faculty of Education, Ain Shams University, Roxy, Heliopolis, P.C.11757, Cairo, Egypt.
The most important tools in killing and overcoming on the microbes and pathogens that cause diseases in medicine and/or in agriculture are the antibiotics. The discovery and synthesis of the microbial natural products or antibiotics has greatly developed genetically and biotechnologically quickly in the last decades. It is necessary to access this great genetic diversity by finding ways to increase the level of expression of these biosynthetic pathways.
View Article and Find Full Text PDF[Skin needle embedding for obese impaired glucose tolerance].
Zhongguo Zhen Jiu
January 2018
Department of TCM, Beijing Fengsheng Special Hospital of Traditional Medical Traumatology and Orthopaedics, Beijing 100033, China.
Objective: To explore the effect difference between the skin needle embedding therapy and western medication for obese impaired glucose tolerance (IGT).
Methods: A total of 300 cases of obese IGT were assigned into an embedding group and a western medication group by random number table, 150 cases in each one. Standardized diagnosis and treatment programs were applied to reduce blood pressure, lipid, weight, and exercise and scientific diet management were used.
Identification of Agents Active against Methicillin-Resistant Staphylococcus aureus USA300 from a Clinical Compound Library.
Pathogens
September 2017
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Methicillin-resistant (MRSA) poses a significant threat for effective treatment of several difficult-to-treat infections in humans. To identify potential new treatment options for MRSA infections, we screened a clinical compound library consisting of 1524 compounds using a growth inhibition assay in 96-well plates. We identified 34 agents which are either bacteriostatic or bactericidal against log-phase clinical MRSA strain USA300.
View Article and Find Full Text PDFIdentification of two regulatory genes involved in carbomycin biosynthesis in Streptomyces thermotolerans.
Arch Microbiol
September 2017
Key Laboratory of Biotechnology of Antibiotics, The National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, No. 1 Tian Tan Xi Li, Beijing, 100050, China.
Carbomycins are 16-membered macrolide antibiotics produced by Streptomyces thermotolerans ATCC 11416. To characterize gene cluster responsible for carbomycin biosynthesis, the draft genome sequences for strain ATCC 11416 were obtained, from which the partial carbomycin biosynthetic gene cluster was identified. This gene cluster was approximately 40 kb in length, and encoding 30 ORFs.
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