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Tirzepatide Reduces LV Mass and Paracardiac Adipose Tissue in Obesity-Related Heart Failure: SUMMIT CMR Substudy.
J Am Coll Cardiol
November 2024
Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas and Imperial College, London UK.
Article Synopsis
- Obesity is linked to heart failure with preserved ejection fraction (HFpEF), characterized by changes in heart structure and increased epicardial adipose tissue (EAT), which can lead to negative health outcomes.
- The SUMMIT trial's CMR substudy aimed to assess how tirzepatide influenced cardiac structure and function in patients with obesity-related HFpEF, focusing on its potential to lower left ventricular (LV) mass and EAT.
- Results showed that tirzepatide treatment significantly reduced LV mass by 11 g and paracardiac adipose tissue by 45 ml compared to placebo, with changes in LV mass correlated to body weight and other cardiac measures.
Surgical planning aided with 3D technologies for management of complex paracardiac tumors.
J Cardiothorac Surg
September 2024
Center for 3D Modeling and Printing, Fundación Cardioinfantil - LaCardio, Bogotá, Colombia.
Article Synopsis
- Accurate diagnosis and treatment of complex cardiac tumors is challenging, especially for surgical resection, but 3D reconstruction and printing can enhance pre-operative planning and care.
- The study reports two patients with rare cardiac conditions, one with cardiac angiosarcoma and the other with IgG4-related disease, where 3D models aided in surgical strategies.
- Both patients experienced successful outcomes, with the angiosarcoma patient receiving chemotherapy and another surgery, while the IgG4 patient had complete tumor resection, demonstrating the utility of 3D printing in surgical planning.
Pilot study to assess the early cardiac safety of carbon ion radiotherapy for intra- and para-cardiac tumours.
Strahlenther Onkol
December 2024
Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.
Purpose: Modern photon radiotherapy effectively spares cardiac structures more than previous volumetric approaches. Still, it is related to non-negligible cardiac toxicity due to the low-dose bath of surrounding normal tissues. However, the dosimetric advantages of particle radiotherapy make it a promising treatment for para- and intra-cardiac tumours.
View Article and Find Full Text PDFThe Diagnostic Association of Radiological and Clinicopathological Parameters in Community-Acquired Pneumonia in Children: A Cross-Sectional Study.
Cureus
February 2024
Department of Paediatrics, Combined Military Hospital Lahore Medical College and Institute of Dentistry, Lahore, PAK.
Background Globally, pneumonia is one of the significant causes of death in children under the age of five years. Assessment of disease severity is essential for clinical decision-making. Clinicians in resource-limited settings use the WHO Integrated Management of Childhood Illness (IMNCI) guidelines to diagnose and treat pneumonia.
View Article and Find Full Text PDFWhat are the implications of radiologically abnormal cardiophrenic lymph nodes in advanced ovarian cancer? An analysis of tumour burden, surgical complexity, same-site recurrence and overall survival.
Eur J Surg Oncol
December 2022
Derby Gynaecological Cancer Centre, University Hospitals of Derby and Bruton NHS Foundation Trust, United Kingdom.
Introduction: Our paper evaluates the relationship between radiologically abnormal cardiophrenic lymph nodes (CPLN) in advanced ovarian cancer and pattern of disease distribution, tumour burden, surgical complexity, rates of cytoreduction and same-site recurrence. Impact of suspicious CPLN and CPLN dissection on overall survival also determined.
Materials And Methods: Retrospective review of index CT imaging for 151 consecutive patients treated for stage III/IV ovarian malignancy in a large UK cancer centre to identify radiologically abnormal CPLN.
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