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Clinical and Laboratory Parameters of Metabolic Syndrome in Chronic Spontaneous Urticaria: A Cross-Sectional Study.
Indian Dermatol Online J
December 2024
Department of Dermatology, Venereology, and Leprosy, GSL Medical College and General Hospital, Rajahmahendravaram, Andhra Pradesh, India.
Background: Chronic spontaneous urticaria (CSU) appears to share some pathomechanisms with metabolic syndrome (MS), such as proinflammatory state, increased oxidative stress, changes in adipokine profile, and coagulation system activation.
Aim And Objectives: To evaluate clinical and laboratory parameters of MS in CSU patients and to assess relationship of MS with duration and severity of CSU, Ig-E, thyroid-stimulating hormone (TSH), C-reactive protein (CRP), and autologous serum skin test (ASST).
Materials And Methods: A hospital-based cross-sectional study was conducted on 131 CSU cases and 131 controls who were age- and sex-matched.
Successful Omalizumab treatment in delayed pressure urticaria as confirmed by stimulation test.
An Bras Dermatol
January 2025
Department of Dermatology, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
Applications of basophil activation test in paediatric allergic diseases.
World Allergy Organ J
December 2024
Department of Pediatrics, Pediatric Allergy and Pulmonology Unit, University of Chieti-Pescara, Chieti, Italy.
Basophilic granulocytes, containing and releasing histamine after a specific allergy stimulation, are directly involved in IgE-mediated allergic reactions. CD63 is a transmembrane protein of secretory lysosomes of basophils and its upregulation is related with the release of histamine to the extracellular space during IgE-mediated allergic reactions. Basophil activation test (BAT) measures the activation of circulating basophils upon the stimulation of living blood cells with specific allergens.
View Article and Find Full Text PDF[Effect of acupuncture combined with bloodletting therapy on mast cell degranulation in urticaria rats].
Zhongguo Zhen Jiu
November 2024
Department of Acupuncture and Moxibustion, First Affiliated Hospital of Hebei University of CM, Shijiazhuang 050011.
Article Synopsis
- The study aimed to investigate the impact of combining acupuncture and bloodletting on inflammatory responses in rats diagnosed with urticaria, focusing on serum markers and skin tissue characteristics.
- Using 42 SD rats, researchers divided them into six groups: a control, a model, a positive drug, an acupuncture, a bloodletting, and a combined treatment group, with specific interventions administered for 14 days.
- After treatment, the researchers measured various inflammatory markers, assessed the skin damage, and analyzed the activity of mast cells to evaluate the effectiveness and potential mechanisms of this therapy for urticaria.
Pharmacological blockade of the mast cell MRGPRX2 receptor supports investigation of its relevance in skin disorders.
Front Immunol
November 2024
Research and Development, GSK, Collegeville, PA, United States.
Introduction: Because MRGPRX2 is now recognized as the mast cell receptor for basic secretagogues, there is currently a tremendous interest in whether MRGRPX2 could play an important role in various pruritic dermatoses such as chronic spontaneous urticaria. Therefore, we sought to identify new potent and selective antagonists to pharmacologically characterize the biological role of MRGPRX2.
Methods: Various relevant , , and model systems were used to investigate the role of MRGPRX2.
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