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Anaphylaxis Following Human Prothrombin Complex Concentrate in a Child with Lupus Anticoagulant Hypoprothrombinemia Syndrome: A Cautionary Tale.
TH Open
January 2018
Queensland Haemophilia Centre, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
A previously healthy 3-year-old girl presented with a short history of mucocutaneous bleeding and a spontaneous left knee hemarthrosis following a nonspecific viral gastroenteritis. Initial investigations for a bleeding disorder revealed a normal platelet count; however, coagulation studies revealed a prothrombin time (PT) of 25 seconds and an activated partial thromboplastin time (APTT) of 66 seconds (both prolonged). The APTT did not correct on mixing with normal plasma, and further testing confirmed the presence of a strong lupus anticoagulant (LA).
View Article and Find Full Text PDFCongenital combined deficiency of coagulation factors VII and II in a young adult.
Conn Med
February 2011
Department of Hematology-Oncology, Saint Francis Hospital and Medical Center, Gothic Park, 43 Woodland Street, Suite G-80, Hartford, CT 06105, USA.
We present herein a case of a young female with congenital combined coagulation factor VII (FVII) and factor II (FII) deficiencies. She was completely asymptomatic and found to have a prolonged prothrombin time during a routine preoperative evaluation. Low levels of plasma FVII and FII in the absence of an inhibitor confirmed the diagnosis in our patient.
View Article and Find Full Text PDF[Specificities of neonatal hemostasis and implications in pathologic situations].
Arch Pediatr
September 2010
Service d'Hématologie-Hémostase, Hôpital Trousseau, 37044 Tours cedex 9, France.
The haemostasis of healthy newborn differs from those of normal adult but remains well balanced without bleeding or thrombosis. However, this equilibrium is unstable, and the neonate is exposed to acquired or inherited haemostasis disorders that necessitate to be early diagnosed in order to be appropriately treated. Several studies provided reference ranges for haemostatic components in the foetus, the newborn and throughout childhood.
View Article and Find Full Text PDFLow plasma concentrations of coagulation factors II, VII and XI indicate increased risk among elderly with symptoms of heart failure.
Blood Coagul Fibrinolysis
January 2010
Department of Cardiology, Heart Center, University Hospital of Linköping, Linköping, Sweden.
Heart failure is a serious condition, and it is, therefore, important to identify patients at high risk as early as possible in order to initiate appropriate treatment. The condition results in complicated disease mechanisms including disturbances in blood coagulation. The aim of the present study was to evaluate whether low plasma concentrations of coagulation factors (F) II, VII and XI influence cardiovascular mortality in an elderly population with possible heart failure.
View Article and Find Full Text PDFProthrombin complex concentrate (Beriplex P/N).
Drugs
October 2009
Adis, a Wolters Kluwer Business, Auckland, New Zealand.
Beriplex P/N, a prothrombin complex concentrate derived from pooled human plasma, contains the vitamin K-dependent coagulation factors II, VII, IX and X, and the vitamin K-dependent coagulation inhibition proteins C and S. Intravenous Beriplex P/N provided rapid and sustained normalization of elevated international normalized ratios and controlled bleeding in adult patients participating in several prospective, noncomparative clinical studies (n = 8-43), with these data supported by clinical experience during its use over more than a decade. Based on extensive clinical experience, Beriplex P/N is also effective in the treatment of congenital deficiency of any of the vitamin K-dependent coagulation factors when purified specific coagulation factor products are not available.
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