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Ketosis regulates K ion channels, strengthening brain-wide signaling disrupted by age.
Imaging Neurosci (Camb)
May 2024
Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY, 11790, USA.
Aging is associated with impaired signaling between brain regions when measured using resting-state fMRI. This age-related destabilization and desynchronization of brain networks reverses itself when the brain switches from metabolizing glucose to ketones. Here, we probe the mechanistic basis for these effects.
View Article and Find Full Text PDFStroke and Stroke-Like Episodes: Recurrent Manifestations in GLUT1 Deficiency Syndrome.
Pediatr Neurol
August 2024
Pediatric Neurology Unit, Buzzi Children's Hospital, Milan, Italy; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. Electronic address:
Article Synopsis
- The study reviewed eight patients with Glut1 deficiency syndrome (Glut1-DS) who experienced episodes of acute neurological deficits, showcasing the condition's expanded phenotype.
- Researchers analyzed clinical and imaging data, revealing symptoms like speech difficulties and paralysis, with MRIs indicating venous issues and some patients showing brain lesions.
- The findings suggest that stroke-like episodes are common in Glut1-DS, especially in young adults, highlighting the need to explore ketogenic diets' effectiveness in preventing such episodes and the link between Glut1-DS and ischemic stroke.
Electroencephalographic abnormalities in children with type 1 diabetes mellitus: a prospective study.
Turk J Med Sci
May 2024
Department of Pediatric Neurology, Diyarbakır Children's Hospital, Diyarbakır, Turkiye.
Background/aim: The aim herein was to investigate epileptiform discharges on electroencephalogram (EEG), their correlation with glutamic acid decarboxylase 65 autoantibody (GAD-ab) in newly diagnosed pediatric type 1 diabetes mellitus (T1DM) patients and interpret their medium-term utility in predicting epilepsy.
Materials And Methods: Children presenting with T1DM between July 2018 and December 2019 were included in this prospective longitudinal study. Patients with a history of head injury, chronic illness, neurological disorder, seizure, autism, or encephalopathy were excluded.
Recovery From Homonymous Hemianopia in Hyperglycemia-Induced Occipital Lobe Electroclinical Seizures Following Glycemic Control.
J Neuroophthalmol
May 2024
Faculty of Medicine (CELW), University of Sydney, Sydney, Australia; Faculty of Medicine (BWHL, JEO, HL-G, SW, ES, AA, MTC, ICF), University of New South Wales, Sydney, Australia; Department of Neurology (JEO, HL-G, SW, ES), Prince of Wales Hospital, Sydney, Australia; and Department of Ophthalmology (AA, MTC, ICF), Prince of Wales Hospital, Sydney, Australia.
Background: Visual changes due to hyperglycemia in diabetes are not uncommon. While blurred vision is a well-established sequela of chronic hyperglycemia, homonymous hemianopia with or without electroclinical seizures is much rarer and can be mistaken for migraine, temporal arteritis, or ischemia of the central nervous system.
Methods: This article analyzed case studies for 3 patients (67M, 68M, 52F) presenting with complex visual phenomena, from 3 to 42 days duration, including pathogenesis, clinical findings, management, and follow-up.
A randomized feasibility trial of medium chain triglyceride-supplemented ketogenic diet in people with Parkinson's disease.
BMC Neurol
April 2024
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Background: A ketogenic diet (KD) may benefit people with neurodegenerative disorders marked by mitochondrial depolarization/insufficiency, including Parkinson's disease (PD).
Objective: Evaluate whether a KD supplemented by medium chain triglyceride (MCT-KD) oil is feasible and acceptable for PD patients. Furthermore, we explored the effects of MCT-KD on blood ketone levels, metabolic parameters, levodopa absorption, mobility, nonmotor symptoms, simple motor and cognitive tests, autonomic function, and resting-state electroencephalography (rsEEG).
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