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Leukocytospermia and/or Bacteriospermia: Impact on Male Infertility.
J Clin Med
May 2024
LogixX Pharma Ltd., Merlin House, Brunel Road, Theale, Reading RG7 4AB, UK.
Infertility is a globally underestimated public health concern affecting almost 190 million people, i.e., about 17.
View Article and Find Full Text PDFTransport of Non-Steroidal Anti-Inflammatory Drugs across an Oral Mucosa Epithelium In Vitro Model.
Pharmaceutics
April 2024
Competence Unit Molecular Diagnostics, AIT Austrian Institute of Technology GmbH, 1210 Vienna, Austria.
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most prescribed drugs to treat pain or fever. However, oral administration of NSAIDs is frequently associated with adverse effects due to their inhibitory effect on the constitutively expressed cyclooxygenase enzyme 1 (COX-1) in, for instance, the gastrointestinal tract. A systemic delivery, such as a buccal delivery, of NSAIDs would be beneficial and additionally has the advantage of a non-invasive administration route, especially favourable for children or the elderly.
View Article and Find Full Text PDFCo-composting of sewage sludge as an effective technology for the production of substrates with reduced content of pharmaceutical residues.
Sci Total Environ
March 2024
FCC Česká republika, s.r.o., Ďáblická 791/89, 182 00 Praha, Czech Republic.
Sewage sludge is a valuable source of elements such as phosphorus and nitrogen. At the same time, heavy metals, emerging organic compounds, micropollutants (pharmaceuticals, pesticides, PCPs, microplastics), or some potentially dangerous bacteria can be present. In this study, the sewage sludge was aerobically treated by composting with other materials (co-composted), and the resulting substrate was tested for suitability of its use in agriculture.
View Article and Find Full Text PDFPain is a serious subjective experience, which, although it has a protective nature, it physically and mentally exhausts the patient. The pharmacological field of development and research in the treatment and relief of pain has been dynamic and interesting ever since the isolation of salicylic acid. After discovering the molecular nature of cyclooxygenase and its inhibition, research focused on selective COX-2 inhibitors, but they were a big disappointment.
View Article and Find Full Text PDFNonsteroidal anti-inflammatory drug monitoring in serum: a Tb-MOF-based luminescent mixed matrix membrane detector with high sensitivity and reliability.
Dalton Trans
January 2023
Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Key Laboratory of Functional Inorganic Materials of Anhui Province, Department of Chemistry, Anhui University, Hefei 230601, P. R. China.
The identification of drugs or biomolecules for public health monitoring requires facile analytical technologies with excellent sensitivity, portability and reliability. In the past decades, different sensing materials have inspired the development of various bioanalytical strategies. However, sensing platforms based on powder materials are not suitable for medical diagnosis, which limits further exploration and application of biosensors.
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