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Anesthesiology
August 2001
Department of Anesthesiology, Pennsylvania State University College of Medicine, Hershey 17033-0850, USA.
Background: Systemic morphine is known to cause increased release of acetyicholine in the spinal cord. Intrathecal injection of the cholinergic receptor agonists or acetyicholinesterase inhibitors produces antinociception in both animals and humans. In the present study, we explored the functional importance of spinal endogenous acetylcholine in the analgesic action produced by intravenous morphine.
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