Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Effect of testosterone treatment during puberty in boys with Klinefelter syndrome (The TIPY Study): protocol for a nationwide randomised, double-blinded, placebo-controlled study.
BMJ Open
March 2025
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Introduction: Klinefelter syndrome (KS) is a genetic condition characterised by the presence of an extra X chromosome in males (47,XXY). KS is associated with various phenotypic characteristics in adult life, including infertility, hypogonadism and increased risk of type II diabetes, cardiovascular disease and osteoporosis. Additionally, individuals with KS often experience mental health challenges and functional impairments that significantly impact their quality of life.
View Article and Find Full Text PDFTransdermal sequential delivery of functionalized Nano-Deep eutectic system for enhanced treatment of melanoma.
Int J Pharm
March 2025
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China. Electronic address:
In the present study, we introduce the concept of "transdermal sequential delivery" as a non-invasive and synergistic approach for the treatment of melanoma. We developed a functionalized Deep Eutectic System (DES) that incorporates both small molecule drugs and nanoparticles. The glycolysis inhibitor 2-deoxy-D-glucose (2-DG) served as the Hydrogen Bond Donor (HBD) to form the DES, while glutathione (GSH)-responsive Mesoporous Organosilicon Nanoparticles (MON) were prepared and encapsulated with chlorin e6 (Ce6).
View Article and Find Full Text PDFImpact of vascular calcifications on the risk of fractures in patients with chronic kidney disease.
Bone
March 2025
INICSA (CONICET-Universidad Nacional de Córdoba), Argentina; Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Argentina. Electronic address:
Background: The decline in kidney function adversely affects mineral and bone disease, leading to decreased bone mass, increased fractures, and vascular calcifications (VC), particularly in advanced CKD stage 5. This study aimed to identify VC markers to eventually develop personalized therapeutic and preventive strategies in Argentina, where data is limited.
Methods: A prospective, observational study included 101 patients on dialysis or pre-dialysis, eligible for kidney transplant at the Private University Hospital of Córdoba from June 2019 to December 2020.
Proteomics of Sternaspis chinensis to understand phosphate biomineralization in annelids.
J Proteomics
March 2025
Key Laboratory of Marine Eco-Environmental Science and Technology, First Institute of Oceanography, MNR, Qingdao 266061, China; Laboratory for Marine Ecology and Environmental Science, Qingdao Marine Science and Technology Center, 266100, China; Qingdao Marine Engineering Survey, Design and Research Institute Co., Ltd, Qingdao, 266061, China. Electronic address:
Organisms with phosphate hard tissues contribute to the evolutionary history of life and global biogeochemical cycles. The annelid Sternaspidae is an important group of phosphate-mineralizing organisms, known for its unique amorphous phosphate ventro-caudal shield. However, the molecular mechanisms underlying the formation of their phosphate shields remain unclear.
View Article and Find Full Text PDFDNA as a Promising Biomaterial for Bone Regeneration and Potential Mechanisms of Action.
Acta Biomater
March 2025
Faculty of Dentistry, University of Toronto, Toronto, Canada, 124 Edward Street, Toronto, ON, M5G 1G6, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto, Canada, 164 College St, Toronto, ON, M5S 3G9, Canada. Electronic address:
DNA nanotechnology has created new possibilities for the use of DNA in tissue regeneration - an important advance for DNA use beyond its paradigmatic role as the hereditary biomacromolecule. Biomaterials containing synthetic or natural DNA have been proposed for several applications including drug and gene delivery, and more recently, as osteoconductive biomaterials. This review provides an in-depth discussion of studies that have used DNA-based materials for biomineralization and/or bone repair, with expansion on the topic of DNA hydrogels specifically, and the advantages they offer for advancing the field of bone regeneration.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!