Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1212/wnl.4.10.739 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomarkers.
Alzheimers Dement
December 2024
Department of Psychiatry, University of Cambridge, Cambridge, UK.
Background: Poor sleep is emerging as an important and modifiable risk factor in the development of dementia. The hypothalamus is the only neuroanatomical site of orexin-producing neurones in the brain and modulates sleep and wakefulness behaviour. Due its small size and lack of defined contrast in conventional neuroimaging acquisitions, relatively little evidence exists as to the role of the hypothalamus in humans in neurodegeneration and sleep quality, and whether it may have mechanistic importance and biomarker candidacy.
View Article and Find Full Text PDFBackground: Sleep disturbances have been identified as a risk factor for developing dementia. The hypothalamus is involved in sleep regulation and may be affected early by neurodegeneration. Our aim was to investigate the relationship between subjective sleep and hypothalamic structure in adults at higher risk of developing dementia.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Background: The hypothalamus is the body's principal homeostatic center and plays a crucial role in the modulation of cognition. However, detailed assessments of age and sex effects on hypothalamic substructural integrity and its cognitive correlates across lifespan are still lacking. Therefore, we aimed to investigate the hypothalamic structural integrity in relation to age, sex and cognitive performance across lifespan in the general population.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Background: Abnormal tau accumulation is first observed in several neuromodulatory subcortical nuclei before its emergence in the allocortex, and long before the first deposits of amyloid-beta (Aβ) plaques. Crucially, the posterior hypothalamus has been put forward as a critical site for Alzheimer's disease (AD) pathogenesis but its role in AD-related processes remains poorly investigated in humans. Here, we aimed to investigate whether the structural integrity of the posterior hypothalamus, as assessed in vivo, is associated with PET-measured AD pathology and cognitive performance in cognitively unimpaired (CU) and impaired older individuals.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
Background: Poor sleep is emerging as an important and modifiable risk factor in the development of dementia. The hypothalamus is the only neuroanatomical site of orexin-producing neurones in the brain and modulates sleep and wakefulness behaviour. Due its small size and lack of defined contrast in conventional neuroimaging acquisitions, relatively little evidence exists as to the role of the hypothalamus in humans in neurodegeneration and sleep quality, and whether it may have mechanistic importance and biomarker candidacy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!