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Acute Pancreatitis in Pregnancy and Puerperium: Assessing Maternal and Fetal Impact, Etiologies, and Clinical Outcomes at a Tertiary Care Hospital in Pakistan.
Cureus
December 2024
Obstetrics and Gynaecology, Aga Khan University Hospital, Karachi, PAK.
Introduction The association of acute pancreatitis with adverse obstetric outcomes remains subject to great controversy. Outcomes are affected by the standard of care available, and hence, will be better in developed countries than in underdeveloped countries like Pakistan. Therefore, this study aimed to understand the clinical characteristics and treatment of acute pancreatitis in pregnancy (APIP) and its associated maternal and neonatal outcomes in a tertiary care hospital in Pakistan.
View Article and Find Full Text PDFThe Association between Pregnancy Complications and Long-Term Maternal Cardiometabolic Health in the MIREC Cohort Study.
J Clin Endocrinol Metab
January 2025
Centre de Recherche du CHUS, and Department of Obstetrics and gynecology, University of Sherbrooke. Sherbrooke, Québec, Canada.
Context: During pregnancy, women who experience certain pregnancy complications show elevations in biomarkers of inflammation and insulin resistance; however, few studies have examined these cardiometabolic biomarkers in the decade following pregnancy.
Objective: To examine the association between pregnancy complications and cardiometabolic biomarkers 9 years postpartum including: blood pressure, blood lipids, body fat percentage, insulin resistance (glucose, insulin, proinsulin, C-peptide, HOMA-IR, HbA1c, leptin, adiponectin) and inflammation (hs-C-reactive protein).
Methods: Using data from the Maternal-Infant Research on Environmental Chemicals (MIREC) cohort study (2008-2021) we determined 3 groups of pregnancy complications: 1) hypertensive disorders of pregnancy (HDP) (n=35); any pregnancy complication in the index pregnancy, defined as preterm birth, HDP, impaired glucose tolerance or gestational diabetes mellitus (GDM) (n=55); or self-reported recurrence of one of these pregnancy complications (n=19).
A Case Report of Spontaneous Pneumomediastinum (Hamman's Syndrome) During Labor.
Cureus
December 2024
Critical Care Medicine, Coordinación de Terapia Intensiva y Hemodinamia de Hospitales de 2º Nivel Instituto Mexicano del Seguro Social Bienestar, Mexico City, MEX.
Hamman's syndrome is characterized by spontaneous pneumomediastinum triggered by Valsalva maneuvers and is an uncommon complication during labor and the postpartum period. It is typically benign and managed conservatively with oxygen therapy and analgesia. We present the clinical case of a 21-year-old primigravida who developed spontaneous pneumomediastinum during labor, manifesting with subcutaneous emphysema and dyspnea.
View Article and Find Full Text PDFThe Linda Kizazi study: a comparison of morbidity and mortality from birth to 2 years between children who are HIV-unexposed and HIV-exposed, uninfected in the era of universal antiretroviral therapy.
BMJ Glob Health
January 2025
Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Article Synopsis
- Children who are HIV-exposed but uninfected (CHEU) have historically shown higher morbidity and mortality rates compared to children who are unexposed (CHUU), prompting a study to assess this in the context of modern antiretroviral therapy.
- The study involved tracking mother-infant pairs for two years in Nairobi, collecting data on illnesses, hospital visits, and feeding practices, focusing on the risks associated with various health outcomes between CHEU and CHUU infants.
- Results indicated that while overall morbidity and mortality rates for CHEU were similar to CHUU, CHEU infants had a significantly lower risk of respiratory tract infections (RTI) and pneumonia.
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