Cerebral cryptic angiomas are vascular malformations with variable histological appearance, but with similar radiological features. Angiography does not usually visualize the lesion. Computer tomography often detects the malformation, but frequently fails to make classify correctly. With magnetic resonance imaging (MRI) the cryptic angioma is studied best on T2 weighted images. The pattern of signal intensities differs both among and within the lesions. Evidence of small hemorrhages of different ages and flow phenomena are seen in all malformations. A total of 51 angiomas were demonstrated in 38 patients by MRI (excluding one patient with a very large number of angiomas). Enhanced or plain CT scans depicted respectively 16 and 6 lesions. In one case angiography was the only way to detect an angioma. Currently, MRI is the most sensitive method for the detection of cerebral cryptic angiomas.
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http://dx.doi.org/10.1016/0303-8467(92)90061-7 | DOI Listing |
J Neurosurg Case Lessons
January 2025
Neurosurgery Clinic, Birgunj, Nepal.
Background: A 71-year-old male presented with weakness of the right upper limb and headache for the past 3 months. Brain magnetic resonance imaging (MRI) with contrast showed a left frontal space-occupying lesion, suggestive of a high-grade malignancy. Awake craniotomy with complete excision of the lesion was performed under immunofluorescence guidance.
View Article and Find Full Text PDFbioRxiv
January 2025
Department of Neuroscience and Waisman Center, University of Wisconsin-Madison.
Here, we report the spatial organization of RNA transcription and associated enhancer dynamics in the human spinal cord at single-cell and single-molecule resolution. We expand traditional multiomic measurements to reveal epigenetically poised and bivalent active transcriptional enhancer states that define cell type specification. Simultaneous detection of chromatin accessibility and histone modifications in spinal cord nuclei reveals previously unobserved cell-type specific cryptic enhancer activity, in which transcriptional activation is uncoupled from chromatin accessibility.
View Article and Find Full Text PDFMol Phylogenet Evol
January 2025
Charles University, Faculty of Science, Department of Zoology, Prague, Czechia.
The phylum Heterolobosea Page and Blanton, 1985 is a group of eukaryotes that contains heterotrophic flagellates, amoebae, and amoeboflagellates, including the infamous brain-eating amoeba Naegleria fowleri. In this study, we investigate the deep evolutionary history of Heterolobosea by generating and analyzing transcriptome data from 16 diverse isolates and combine this with previously published data in a comprehensive phylogenomic analysis. This dataset has representation of all but one of the major lineages classified here as orders.
View Article and Find Full Text PDFMov Disord
January 2025
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Background: Perry syndrome (PS) is a rare and fatal hereditary autosomal dominant neurodegenerative disorder caused by mutations in dynactin (DCTN1). PS brains accumulate inclusions positive for ubiquitin, transactive-response DNA-binding protein of 43 kDa (TDP-43), and to a lesser extent dynactin.
Objectives: Little is known regarding the contributions of TDP-43, an RNA binding protein that represses cryptic exon inclusion, in PS.
Eur J Hum Genet
January 2025
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India.
Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a rare neurodegenerative disorder characterized by spastic paraplegia, parkinsonism and psychiatric and/or behavioral symptoms caused by variants in gene encoding chromosome-19 open reading frame-12 (C19orf12). We present here seven patients from six unrelated families with detailed clinical, radiological, and genetic investigations. Childhood-onset patients predominantly had a spastic ataxic phenotype with optic atrophy, while adult-onset patients were presented with cognitive, behavioral, and parkinsonian symptoms.
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