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Assessment of Lactobacillus acidophilus (L. acidophilus) therapeutic and prophylactic role in rats experimentally infected with Blastocystis subtype 3 (ST3).
Parasitol Res
January 2025
Medical Parasitology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Blastocystis, an eukaryote, inhabits the intestinal tract of humans and animals worldwide. Lactobacillus acidophilus (L. acidophilus), a probiotic, has been reported to be effective against blastocystosis.
View Article and Find Full Text PDFFrequency and Distribution of Parasites Detected in Children Between 2017-2022 (6-year Period).
Turkiye Parazitol Derg
January 2025
Sağlık Bilimleri Üniversitesi, Dr. Behçet Uz Çocuk Hastalıkları ve Cerrahisi Eğitim Araştırma Hastanesi, Mikrobiyoloji Laboratuvarı, İzmir, Türkiye.
Objective: In the study, various complaints such as gastrointestinal complaints such as diarrhea, constipation, abdominal pain, nausea and vomiting, weight loss, night urination, itching around the anus, malnutrition, malabsorption, anemia, intelligence and developmental delay were reported to University of Health Sciences Türkiye, Dr. Behçet Uz Pediatric Diseases and Surgery Training and Researhc Hospital, Microbiology Laboratory between 2017 and 2022. It was aimed to determine the frequency and distribution of intestinal parasites in patients presenting with clinical symptoms.
View Article and Find Full Text PDFEhVps35, a retromer component, is involved in the recycling of the EhADH and Gal/GalNac virulent proteins of .
Front Parasitol
March 2024
Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional [CINVESTAV-Instituto Politécnico Nacional (IPN)], Mexico City, Mexico.
The retromer is a highly conserved eukaryotic complex formed by the cargo selective complex (CSC) and the sorting nexin (SNX) dimer subcomplexes. Its function is protein recycling and recovery from the endosomes to conduct the target molecules to the trans-Golgi network or the plasma membrane. The protozoan responsible for human amoebiasis, , exhibits an active membrane movement and voracious phagocytosis, events in which the retromer may be fully involved.
View Article and Find Full Text PDFPRMT5 Inhibitor EPZ015666 Decreases the Viability and Encystment of .
Molecules
December 2024
Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City 07360, Mexico.
Protein arginine methyltransferase 5 (PRMT5) is an enzyme that produces monomethyl arginine (MMA) and symmetric dimethyl arginine (sDMA), post-translational modifications that regulate several cellular processes, including stage conversion in parasitic protozoans. , the etiologic agent of human amebiasis, has two stages in its life cycle, the trophozoite, which is the replicative form, and the cyst, corresponding to the infective phase. The study of the molecular mechanisms that regulate differentiation in this parasite has been overdue because of a lack of efficient protocols for in vitro encystment.
View Article and Find Full Text PDFExploring the Interactome of the Queuine Salvage Protein DUF2419 in .
Cells
November 2024
Department of Molecular Microbiology, Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3525433, Israel.
causes amebiasis, a significant global health issue, with millions affected annually, especially in developing countries. EhDUF2419, an important protein involved in 's queuine salvage pathway and its interaction network, remains unclear. To explore this, we transfected trophozoites with a plasmid encoding Myc-tagged EhDUF2419 and achieved successful overexpression.
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