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Evaluation of anxiolytic activity of tensarin in mice.
Kathmandu Univ Med J (KUMJ)
December 2010
Department of Pharmacology, BP Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal.
Introduction: Anxiolytic drugs are amongst the most frequently prescribed drugs. Available anxiolytic agents are associated with several limitations. Several indigenous drugs are being evaluated but none has been proved to be effective.
View Article and Find Full Text PDFMicroPET II: design, development and initial performance of an improved microPET scanner for small-animal imaging.
Phys Med Biol
June 2003
UCLA, Crump Institute for Molecular Imaging, Los Angeles, CA 90095-1770, USA.
MicroPET II is a second-generation animal PET scanner designed for high-resolution imaging of small laboratory rodents. The system consists of 90 scintillation detector modules arranged in three contiguous axial rings with a ring diameter of 16.0 cm and an axial length of 4.
View Article and Find Full Text PDFSequestration ofVeratrum alkaloids by specialistRhadinoceraea nodicornis konow (Hymenoptera, Tenthredinidae) and its ecoethological implications.
J Chem Ecol
December 1994
Institute of Zoology, University of Bern, Baltzerstrasse 3, CH-3012, Bern, Switzerland.
The larvae of the specialist sawflyRhadinoceraea nodicornis Konow (Hymenoptera, Tenthredinidae) store in their hemolymph ceveratrum alkaloids originating from the host plantVeratrum album L. (Liliales, Melanthiaceae). The major alkaloid found in the hemolymph is 3-acetyl-zygadenine.
View Article and Find Full Text PDFK+ fluxes of rat cortical synaptosomes were monitored by a K+ sensitive ion-selective membrane electrode. The uptake phases of K+curves from control and experimental measurements were compared and statistically evaluated. GABA significantly reduced K+ uptake but it was able to reverse the decrease of K+ uptake caused by protoveratrine.
View Article and Find Full Text PDFThis study was undertaken to evaluate functionally the time and pattern of inotropic and chronotropic efferent cardiac reinnervation of the deneravated canine heart and to correlate functional data with regional myocardial catecholamine content and supersensitivity to norepinephrine. Our data indicate that efferent autonomic reinnervation takes place first in the atria, followed by a base-to-apex sequence in the ventricles, and that such reinnervation is functionally effective 9-12 mo after denervation. The return of neural function parallels the return of measurable quantities of myocardial norepinephrine and is accompanied by a decrease in supersensitivity to exogenous norepinephrine.
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