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Anticoagulation-related complications and their outcomes in hemodialysis patients with acute kidney injury at selected hospitals in Ethiopia.
PLoS One
December 2024
Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Collage of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Introduction: During hemodialysis (HD), the presence of clots in the dialyzer can diminish the effective surface area of the device. In severe cases, clot formation in the circuit can halt treatment and lead to blood loss in the system. Thus, ensuring proper anticoagulation during HD is crucial to prevent clotting in the circuit while safeguarding the patient from bleeding risks.
View Article and Find Full Text PDFReduction in Renal Heme Oxygenase-1 Is Associated with an Aggravation of Kidney Injury in Shiga Toxin-Induced Murine Hemolytic-Uremic Syndrome.
Toxins (Basel)
December 2024
Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany.
Hemolytic-uremic syndrome (HUS) is a systemic complication of an infection with Shiga toxin (Stx)-producing enterohemorrhagic , primarily leading to acute kidney injury (AKI) and microangiopathic hemolytic anemia. Although free heme has been found to aggravate renal damage in hemolytic diseases, the relevance of the heme-degrading enzyme heme oxygenase-1 (HO-1, encoded by ) in HUS has not yet been investigated. We hypothesized that HO-1 also important in acute phase responses in damage and inflammation, contributes to renal pathogenesis in HUS.
View Article and Find Full Text PDFComparative study of Claude 3.5-Sonnet and human physicians in generating discharge summaries for patients with renal insufficiency: assessment of efficiency, accuracy, and quality.
Front Digit Health
December 2024
Department of Medical Education, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: The rapid development of artificial intelligence (AI) has shown great potential in medical document generation. This study aims to evaluate the performance of Claude 3.5-Sonnet, an advanced AI model, in generating discharge summaries for patients with renal insufficiency, compared to human physicians.
View Article and Find Full Text PDFA novel scoring system for the prediction of disease severity in STEC-HUS.
Pediatr Int
December 2024
Department of Pediatrics, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
Background: Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS) is a life-threatening condition complicated by acute kidney injury, acute respiratory distress syndrome, and central nervous system disorders. The early identification of high-risk patients is required to facilitate timely and appropriate treatment.
Methods: The medical records of patients with STEC-HUS treated at 11 hospitals in Hokkaido, Japan, were reviewed retrospectively.
Coronavirus Disease 2019-Associated Thrombotic Microangiopathy: A Single-Center Experience.
Int J Mol Sci
November 2024
Department of Nephrology, University Medical Center Ljubljana, 1000 Ljubljana, Slovenia.
Article Synopsis
- COVID-19 can lead to multiorgan issues, including thrombotic microangiopathy (TMA), which we studied in eight patients at our center.
- Most patients showed few COVID-19 symptoms, and TMA occurred after the virus was present in their system; two had additional non-COVID-related factors triggering TMA.
- Treatments varied based on the type of TMA, with some achieving recovery in blood and kidney functions, highlighting the need for tailored treatment approaches due to different causes and responses.
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