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Leptomeningeal Disease Secondary to Invasive Ductal Carcinoma of the Breast: A Rapidly Progressive and Fatal Complication.
Cureus
November 2024
Internal Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, GBR.
Leptomeningeal disease (LMD) is a rare yet serious complication of advanced malignancy, often seen in breast cancer and associated with a poor prognosis. This case report highlights the rapid progression and diagnostic challenges encountered in a woman in her 40s with advanced breast cancer who presented with severe headaches, absence seizures, and diplopia. The patient's complex past history included invasive ductal carcinoma, prior brain metastasis, and recent craniotomy, which added significant challenges to diagnosis and management.
View Article and Find Full Text PDFRetrospective validation of automatic sleep analysis with grey areas model for human-in-the-loop scoring approach.
J Sleep Res
October 2024
Department of Technical Physics, University of Eastern Finland, Kuopio, Finland.
State-of-the-art automatic sleep staging methods have demonstrated comparable reliability and superior time efficiency to manual sleep staging. However, fully automatic black-box solutions are difficult to adapt into clinical workflow due to the lack of transparency in decision-making processes. Transparency would be crucial for interaction between automatic methods and the work of sleep experts, i.
View Article and Find Full Text PDFA Complex Case: Tubercular Pleural Effusion, Infarct, and Multisystem Involvement.
Cureus
September 2024
Department of Surgery, Bharati Vidyapeeth Hospital, Pune, IND.
Article Synopsis
- Tuberculous pleural effusion, a common complication of tuberculosis, presents significant diagnostic and treatment challenges, especially in patients with several health issues.
- A 58-year-old woman with multiple comorbidities was diagnosed with tuberculous pleural effusion following symptoms of fever, dyspnea, and a blunted angle seen on chest X-ray.
- After developing neurological symptoms, a CT scan revealed a brain infarct while the cerebrospinal fluid tested negative for tuberculosis, emphasizing the need for a timely and coordinated treatment strategy for such complex cases.
Status epilepticus in tuberculous meningitis.
Epilepsy Behav
October 2024
Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli, Road, Lucknow, Uttar Pradesh 226014, India.
Objective: There is paucity of information about status epilepticus (SE) in tuberculous meningitis (TBM). In this communication, we report SE semiology, response to antiseizure medication (ASM) and outcome of the TBM patients with SE.
Methods: The diagnosis of TBM was based on clinical, cerebrospinal fluid and MRI findings.
Occurrence and determinants of seizures and their impact on tuberculous meningitis: a prospective evaluation.
Acta Neurol Belg
June 2024
Department of Microbiology, King George Medical University, Lucknow, Uttar Pradesh, 22600, India.
Objective: To assess the incidence of seizures and the factors contributing to poor outcomes in patients with tuberculous meningitis (TBM).
Methods: In this prospective observational study, 129 patients with TBM were enrolled at the Department of Neurology, King George's Medical University, Uttar Pradesh, India, from April 2021 to April 2023. Detailed clinical history, neurological examinations, baseline laboratory tests, contrast-enhanced Magnetic resonance imaging (MRI) and electroencephalography (EEG) were obtained for all patients.
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