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Preferred Orientation of Hydroxyapatite Ceramics Along the -Axis Promotes Osteoblast Differentiation.
Int J Mol Sci
December 2024
Department of Applied Chemistry, School of Science and Technology, Meiji University, Kawasaki 214-8571, Kanagawa, Japan.
Hydroxyapatite (HAp) is similar to the main inorganic components of bone and tooth enamel. Furthermore, it possesses biocompatibility, making it suitable for clinical use in artificial bones. This study aimed to verify whether the preferred orientation of HAp influences osteogenesis.
View Article and Find Full Text PDFOsteogenic tailoring of oriented bone matrix organization using on/off micropatterning for osteoblast adhesion on titanium surfaces.
Acta Biomater
January 2025
Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:
Article Synopsis
- Titanium implants are recognized for their strength and stability, essential for effective bone healing, but improving the biological activity of their surfaces presents challenges.
- A new micropatterned titanium substrate using a special polymer (MPC) has been developed to precisely control bone matrix organization, promoting better cell alignment and tissue formation.
- This innovative material enhances bone regeneration by activating the Wnt/β-catenin signaling pathway in cells, setting the stage for tailored medical devices that can actively restore bone microstructure.
High-filler content electrospun fibers from biodegradable polymers and hydroxyapatite: Toward improved scaffolds for tissue engineering.
Polim Med
December 2024
Department of Polymer Engineering and Technology, Faculty of Chemistry, Wroclaw University of Science and Technology, Poland.
Background: One of the key challenges in tissue engineering area is the creation of biocompatible scaffolds that support cell growth and mimic the structural and mechanical properties of native tissues. Among various materials used for scaffold fabrication, composite materials based on biodegradable polymers reinforced with bioactive inorganic fillers have attracted significant attention due to their properties. One of the important problems with the preparation of composite electrospun fibers is the low filler content in the fiber.
View Article and Find Full Text PDFDeoxygenated hydroxyapatite inhibits macrophage inflammation through fibronectin restricted adsorption.
Acta Biomater
January 2025
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China. Electronic address:
Macrophages can determine the ultimate outcome of the foreign body reaction (FBR). Although researchers confirmed that differences in the elemental composition of the implant interface can lead to varying levels of biological function, the mechanism underlying the polarization directions of macrophages induced by varying oxygen proportions remains unclear. This research presented the fabrication of a deoxygenated hydroxyapatite (dHAP) surface to investigate the impact of oxygen content on macrophage activation.
View Article and Find Full Text PDFA biodegradable, osteo-regenerative and biomechanically robust polylactide bone screw for clinical orthopedic surgery.
Int J Biol Macromol
December 2024
State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu, China.
Article Synopsis
- Poly (L-lactic acid) (PLLA) is a potential orthopedic implant material due to its strength and biodegradability, but faces challenges like low toughness and osteoinductivity.
- This study aims to improve PLLA by using flexible fibers and hydroxyapatite (HA) in a composite structure, which enhances toughness and structural integrity for better bone fixation.
- Testing showed a significant increase in toughness and elongation at break, along with in vivo studies confirming the osteogenic potential of the new bone screws, paving the way for improved PLLA-based fixation devices.
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