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Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response.
Mol Syst Biol
January 2025
Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
The DNA-damaging agent Gemcitabine (GEM) is a first-line treatment for pancreatic cancer, but chemoresistance is frequently observed. Several clinical trials investigate the efficacy of GEM in combination with targeted drugs, including kinase inhibitors, but the experimental evidence for such rationale is often unclear. Here, we phenotypically screened 13 human pancreatic adenocarcinoma (PDAC) cell lines against GEM in combination with 146 clinical inhibitors and observed strong synergy for the ATR kinase inhibitor Elimusertib in most cell lines.
View Article and Find Full Text PDFCognitive Domains in the National Social Life, Health, and Aging Project.
J Gerontol B Psychol Sci Soc Sci
January 2025
Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
Objectives: Cognition consists of specific domains that are differentially linked to health outcomes. We provide guidance on how to derive cognitive domains in the National Social Life, Health, and Aging Project (NSHAP) study. We suggest the use of a bifactor analysis to derive cognitive domains.
View Article and Find Full Text PDFMolecular mechanisms of inverse agonism via κ-opioid receptor-G protein complexes.
Nat Chem Biol
January 2025
The Bridge Institute, Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Opioid receptors, a subfamily of G protein-coupled receptors (GPCRs), are key therapeutic targets. In the canonical GPCR activation model, agonist binding is required for receptor-G protein complex formation, while antagonists prevent G protein coupling. However, many GPCRs exhibit basal activity, allowing G protein association without an agonist.
View Article and Find Full Text PDFSustainable nanomaterials: the role of Cyrene in optimising carbon nanotubes dispersion and filtration efficiency.
Front Chem
December 2024
Circa Renewable Chemistry Institute, Department of Chemistry, University of York, York, United Kingdom.
This study focuses on the fabrication and characterisation of single-walled carbon nanotube (SWCNT) buckypapers and polyethersulfone (PES) flat-sheet membranes using Cyrene, aiming toevaluate its efficacy as a green solvent for these applications. Pristine SWCNTs were dispersed inCyrene without surfactants and compared to N-Methyl-2-pyrrolidone (NMP) dispersions. Buckypapers were fabricated from these dispersions and characterised using Scanning ElectronMicroscopy (SEM), Atomic Force Microscopy (AFM), and infrared spectroscopy.
View Article and Find Full Text PDFCorrigendum to "A systematic review of community-based interventions to address perinatal mental health" [Seminars in Perinatology, 48(6), 2024, 151945].
Semin Perinatol
December 2024
Columbia University School of Nursing, 560W 168th St, New York, NY 10032, USA. Electronic address:
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