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Rocaglamide reprograms glucose metabolism in erythroleukemic cells via c-MYC transcriptional regulation of TXNIP and HK2.
J Ethnopharmacol
January 2025
Natural Products Research Center of Guizhou Province, Guiyang, 550014, China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China. Electronic address:
Ethnopharmacological Relevance: The theory of traditional Chinese medicine (TCM) views leukemia as an imbalance between cell growth and death mainly caused by blood stasis. Medicinal plants Aglaia Lour. (family Meliaceae) are traditionally used as folk medicine in China.
View Article and Find Full Text PDFGrowth hormone is involved in GATA1 gene expression via STAT5B in human erythroleukemia and monocytic cell lines.
Blood Cells Mol Dis
February 2025
Medicine & Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo 663-8179, Japan; Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan. Electronic address:
Article Synopsis
- GATAs are a transcription factor family with six members, where GATA1 and GATA2 are crucial for the development of specific blood cells like erythrocytes and eosinophils.
- The study explores whether growth hormone (GH) acts as an external stimulant for GATA1 expression in blood cell lines, employing various lab techniques to assess this relationship.
- Results indicate that GH enhances GATA1 expression through a pathway involving the GHR/JAK/STAT5 signaling mechanism, indicating its role in the proliferation of hematopoietic cells.
A rare case report of hemophagocytic lymphohistiocytosis secondary to pure eythroid leukemia in a person living with HIV.
Int J STD AIDS
November 2024
Department of General Medicine, Government Medical College and Hospital, Chandigarh, India.
Pure erythroid leukemia (AML-M6) is a rare variant of acute myeloid leukemia (AML) with predominant erythroid lineage proliferation. The incidence of AIDS defining cancers including Kaposi sarcoma and non-Hodgkins lymphoma are on declining trends due to effective use of HAART (Highly Active Antiretroviral Therapy). Correspondingly, there have been increasing cases of leukemia in persons living with HIV.
View Article and Find Full Text PDFAcute Erythroid Leukemia Post-Chemo-Radiotherapy and Autologous Stem Cell Transplantation Due to Multiple Myeloma: Tracing the Paths to Leukemic Transformation.
Int J Mol Sci
July 2024
Department of Pathology, Faculty of General Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Article Synopsis
- * AEL is characterized by specific genetic changes, including multi-allelic mutations, and can develop after treatments like chemotherapy and stem cell transplants, as seen in two case studies.
- * Several potential mechanisms for AEL's development post-treatment are proposed, including the presence of abnormal stem cells, survival of mutated cells after chemotherapy, and new mutations arising from treatment-related complications.
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