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Drug resistance in drug-resistant tuberculosis patients with and without diabetes mellitus: a comparative analysis.
BMC Infect Dis
August 2024
Department of Clinical Laboratory Medicine, Wenzhou Central Hospital, The Ding Li Clinical College of Wenzhou Medical University, Wenzhou, 325000, China.
Background: This dual burden of tuberculosis (TB) and diabetes mellitus (DM) has become a global public health concern. This study aims to compare drug resistance in drug-resistant tuberculosis (DR-TB) patients with and without DM and analyse the risk factors of multidrug-resistant tuberculosis (MDR-TB).
Methods: A total of 893 DR-TB patients were admitted to Wenzhou Central Hospital between January 2018 and December 2022.
Background: Current tuberculosis treatment regimens primarily rely on phenotypic drug susceptibility testing and rapid molecular assays. Although whole-genome sequencing (WGS) offers a promising alternative, disagreements between phenotypic and molecular testing methods remain. In this retrospective study, we compared the phenotypic and WGS-predicted drug resistance profiles of paired isolates with small genetic distances (≤10 single nucleotide variants) obtained from patients with longitudinal single-episode or recurrent tuberculosis.
View Article and Find Full Text PDFEpidemiological, clinical, biochemical, and treatment characteristics of brucellosis cases in Turkey.
J Infect Dev Ctries
July 2024
Karadeniz Technical University Faculty of Medicine, Farabi Hospital, Infectious Diseases and Clinical Microbiology Department, Trabzon, Turkey.
Article Synopsis
- The study assessed the epidemiological characteristics and treatment effectiveness of brucellosis in patients with different organ issues over a decade, focused on data from two medical centers.
- The research included 297 patients, primarily farmers, highlighting that farming and raw dairy consumption were key transmission routes, with high positivity in diagnostic tests and various blood-related conditions reported.
- Findings indicated that treatments with doxycycline combined with either streptomycin or rifampicin were equally effective, with similar relapse rates, suggesting that careful monitoring and longer treatment durations could help reduce the risk of relapse.
S-Nitrosylation-mediated coupling of DJ-1 with PTEN induces PI3K/AKT/mTOR pathway-dependent keloid formation.
Burns Trauma
December 2023
Department of Burn and Plastic Surgery, the First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou 510080, China.
Background: Keloids are aberrant dermal wound healing characterized by invasive growth, extracellular matrix deposition, cytokine overexpression and easy recurrence. Many factors have been implicated as pathological causes of keloids, particularly hyperactive inflammation, tension alignment and genetic predisposition. S-Nitrosylation (SNO), a unique form of protein modification, is associated with the local inflammatory response but its function in excessive fibrosis and keloid formation remains unknown.
View Article and Find Full Text PDFRepurposing of Tuberculosis Drug Candidates for the Treatment of Mycobacterium ulcerans Disease.
Chimia (Aarau)
September 2023
Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123 Allschwil, Switzerland.
Buruli ulcer (BU) is a chronic necrotizing skin disease caused by Mycobacterium ulcerans. Historically, the disease was treated by surgical excision of the skin lesions, until an 8-week combination therapy of rifampicin and streptomycin was introduced in 2004. This treatment modality was effective and reduced recurrence rates.
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