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Antarmycins: Discovery, Biosynthesis, Anti-pathogenic Bacterial Activity, and Mechanism of Action from Deep-Sea-Derived .
JACS Au
January 2025
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
The rapid emergence of antimicrobial-resistant pathogenic microbes has accelerated the search for novel therapeutic agents. Here we report the discovery of antarmycin A (), an antibiotic containing a symmetric 16-membered macrodiolide core with two pendant vancosamine moieties, one of which is glucosylated, from deep-sea-derived SCSIO 07407. The biosynthetic gene cluster of was identified on a giant plasmid featuring transferable elements.
View Article and Find Full Text PDFA review on the screening methods for the discovery of natural antimicrobial peptides.
J Pharm Anal
January 2025
School of Medicine, Foshan University, Foshan, Guangdong, 528000, China.
Natural antimicrobial peptides (AMPs) are promising candidates for the development of a new generation of antimicrobials to combat antibiotic-resistant pathogens. They have found extensive applications in the fields of medicine, food, and agriculture. However, efficiently screening AMPs from natural sources poses several challenges, including low efficiency and high antibiotic resistance.
View Article and Find Full Text PDFAntimycobacterial and Antifungal Activities of Leaf Extracts From .
Scientifica (Cairo)
December 2024
Department of Therapeutics, Natural Products Unit, Wilkins Hospital Block C, Cnr J. Tongogara and R. Tangwena, The African Institute of Biomedical Research and Technology (AiBST), Harare, Zimbabwe.
The global problem of infectious and deadly diseases caused by microbes such as candida and mycobacteria presents major scientific and medical challenges. Antimicrobial drug resistance is a rapidly growing problem with potentially devastating consequences. Various pathogens can cause skin infections, such as bacteria, fungi, and parasites.
View Article and Find Full Text PDFAntibacterial Activity of Peruvian Species: A Comparative Study of the Antimicrobial Effects of Extracts From Three Different Species, , and , Against Human Pathogens.
Int J Microbiol
January 2025
Universidad Nacional de San Agustín, Arequipa 04000, Peru.
The growing problem of antibiotic resistance has driven the search for new sources of antimicrobial agents. Plants, particularly those from the Malvaceae family, have showed promising potential in this field. The present study is based on extracts, and the antimicrobial action was assessed using and as experimental bacterial strains.
View Article and Find Full Text PDFEffect of Artemisia annua on anticoccidial action, intestinal microbiota and metabolites of Hu lambs.
BMC Vet Res
January 2025
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, Henan, China.
Background: Coccidia are among the primary pathogens causing diarrhea and even fatalities in lambs. With the increasing use of chemical drugs to treat coccidiosis, the problem of drug resistance is becoming more and more threatening. Therefore, there is an urgent need to identify novel alternative drugs for the treatment of the lamb coccidia.
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