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Toluene is a cerebral artery constrictor acting via BK channels.
Neuropharmacology
March 2025
Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38103, USA. Electronic address:
Acute intoxication by toluene usually follows intentional inhalation to achieve a "high", which may lead to repeated use due to toluene's reinforcing properties. In both acute and chronic intoxication brain function is primarily affected. Neuronal and glial elements participate in toluene's reinforcing properties and chronic toxicity, yet the targets underlying acute toxicity remain unknown.
View Article and Find Full Text PDFCase Report: Nephrocalcinosis in an infant due to vitamin-D food supplement overdose.
Front Pediatr
November 2024
Hospital Pharmacy, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella, Italy.
Article Synopsis
- Vitamin D is crucial for calcium regulation and overall health, with infants needing 400 IU daily, but the supplement market lacks consistent regulations that can lead to risks.
- A case study of a 22-month-old girl shows how an overdose—25 times the recommended dosage—led to nephrocalcinosis and various symptoms due to excessive vitamin D intake from an online supplement.
- This incident underscores the dangers of self-administering vitamin D without medical supervision, highlighting the need for cautious healthcare guidance on vitamin D supplementation.
Use of intravenous calcium in emergencies to treat patients with hyperkalemia and digoxin poisoning and its impact on short-term outcome.
Med Clin (Barc)
November 2024
Área de Urgencias, Hospital Clínic Barcelona, IDIBAPS, Universitat de Barcelona, Barcelona, España.
Objetives: Patients with digitalis intoxication (DI) and hyperkalaemia are frequently encountered in the emergency department (ED). This alteration may require intravenous (iv) calcium, but its administration has been considered to increase cardiotoxicity and mortality in patients with DI. We studied the effect of iv calcium on mortality and 30-day readmission in patients with hyperkalaemia and DI.
View Article and Find Full Text PDFHispidol Regulates Behavioral Responses to Ethanol through Modulation of BK Channels: A Novel Candidate for the Treatment of Alcohol Use Disorder.
Molecules
September 2024
College of Pharmacy, Woosuk University, Wanju 55338, Republic of Korea.
Alcohol use disorder (AUD) is the most common substance use disorder and poses a significant global health challenge. Despite pharmacological advances, no single drug effectively treats all AUD patients. This study explores the protective potential of hispidol, a 6,4'-dihydroxyaurone, for AUD using the model system.
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