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- Mitochondria play a crucial role in energy production, and recent findings link certain mutations in mitochondrial DNA (mtDNA) to the development of atherosclerosis, a chronic disease affecting arteries.
- This study aimed to investigate the relationship between oxygen consumption in cells and these atherosclerosis-related mtDNA mutations to better understand their role in disease progression.
- Results showed that specific mtDNA mutations are associated with reduced cellular respiration, indicating they could potentially contribute to the mechanisms of atherosclerosis and suggest new targets for treatment.
Imbalance of Plasma Copper and Zinc Levels and the Association Between the Cu/Zn Ratio and Lipid Peroxidation in Algerian Bipolar Patients.
Biol Trace Elem Res
June 2024
Division of Adults, Hospital Center of Rouvray, 76,600, Rouen, France.
Trace elements, through their interaction with biomolecules, can play an important role in the pathophysiology of bipolar disorder and protect against oxidative stress effects. The purpose of this study is to examine plasma concentration levels of zinc (Zn) and copper (Cu) of Algerian patients, diagnosed with bipolar disorder, and to compare these levels with those of healthy controls. The Cu/Zn ratio was calculated to explore a possible correlation between these elements and lipid peroxidation in the study groups.
View Article and Find Full Text PDFRadiation-Chemical Oxygen Depletion Depends on Chemical Environment and Dose Rate: Implications for the FLASH Effect.
Int J Radiat Oncol Biol Phys
September 2023
Radiation Oncology Department, University of Pennsylvania, Philadelphia, Pennsylvania.
Purpose: FLASH (dose rates >40 Gy/s) radiation therapy protects normal tissues from radiation damage, compared with conventional radiation therapy (∼Gy/m). Radiation-chemical oxygen depletion (ROD) occurs when oxygen reacts with radiation-induced free radicals, so a possible mechanism for FLASH involves radioprotection by the decreased oxygen as ROD occurs. High ROD rates would favor this mechanism, but prior studies have reported low ROD values (∼0.
View Article and Find Full Text PDFAdvances on Hormones and Steroids Determination: A Review of Voltammetric Methods since 2000.
Membranes (Basel)
December 2022
Faculty of Material Sciences and Ceramics, AGH University of Science and Technology, av. Mickiewicza 30, 30-059 Kraków, Poland.
Article Synopsis
- * Voltammetric and polarographic methods are highlighted as sensitive, straightforward alternatives to more complex analytical approaches.
- * The article discusses the design improvements in working electrodes and provides a comparison of results for various measured compounds.
Characterizing the Electron Transport Chain: Functional Approach Using Extracellular Flux Analyzer on Mouse Tissue Samples.
Methods Mol Biol
July 2022
Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.
The Seahorse Extracellular Flux Analyzer enables the high-throughput characterization of oxidative phosphorylation capacity based on the electron transport chain organization and regulation with relatively small amount of material. This development over the traditional polarographic Clark-type electrode approaches make it possible to analyze the respiratory features of mitochondria isolated from tissue samples of particular animal models. Here we provide a description of an optimized approach to carry out multi-well measurement of O consumption, with the Agilent Seahorse XFe96 analyzer on mouse brain and muscles to determine the tissue-specific oxidative phosphorylation properties.
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