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A novel mouse model of image-guided radiation-induced acute kidney injury using SARRP.
Biochem Biophys Res Commun
January 2025
Korea Radioisotope Center for Pharmaceuticals, Korea Institute of Radiological & Medical Sciences, Seoul, South Korea. Electronic address:
Radiation therapy is crucial for cancer treatment, but it often causes tissue damage. The kidney, which is sensitive to radiation, is under-researched in this context. This study aimed to develop a mouse model for radiation-induced acute kidney injury (AKI) using a small animal radiation research platform (SARRP) to mimic clinical radiation conditions.
View Article and Find Full Text PDFNear Infrared Photoimmunotherapy for Locoregionally Recurrent Oropharyngeal Squamous Cell Carcinoma at Tongue Base After Chemoradiotherapy: A Case Report and Literature Review.
Cureus
November 2024
Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, JPN.
Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed treatment. We report a successful case of NIR-PIT for post-irradiation locoregionally recurrent oropharyngeal cancer at the tongue base. A 60-year-old man following primary treatment for oropharyngeal cancer at the tongue base by endoscopy (rT1N0M0).
View Article and Find Full Text PDFDynamic response to short-pulsed U-ion beams of material candidates for vacuum beam windows manufacturing.
Heliyon
December 2024
University of Münster, Schlossplatz 2, Münster, 48149, Germany.
The introduction of next-generation extremely energetic particle accelerator facilities, such as the High-Luminosity upgrade of the LHC (HL-LHC) or the proposed future circular collider (FCC), will dramatically increase the energy stored in the circulating particle beams. This will critically affect the thermo-physical and mechanical properties of the materials adopted, possibly compromising their reliability during the operating lifetime. In this scenario, it is paramount to assess the dynamic thermo-mechanical response of materials presently used, or being developed for future use, in beam intercepting devices exposed to potentially destructive events caused by the impact of energetic particle beams.
View Article and Find Full Text PDFParticipation of lipids in the tumor response to photodynamic therapy and its exploitation for therapeutic gain.
J Lipid Res
December 2024
Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Hydroperoxides of unsaturated membrane lipids (LOOHs) are the most abundant non-radical intermediates generated by photodynamic therapy (PDT) of soft tissues such as tumors and have far longer average lifetimes than singlet oxygen or oxygen radicals formed during initial photodynamic action. LOOH-initiated post-irradiation damage to remaining membrane lipids (chain peroxidation) or to membrane-associated proteins remains largely unrecognized. Such after-light processes could occur during clinical oncological PDT, but this is not well-perceived by practitioners of this therapy.
View Article and Find Full Text PDFEnergy metabolism rewiring following acute UVB irradiation is largely dependent on nuclear DNA damage.
Free Radic Biol Med
December 2024
Univ. Bordeaux, Inserm, BRIC, UMR 1312, F-33076, Bordeaux, France; Aquiderm, University of Bordeaux, Bordeaux, France. Electronic address:
Solar ultraviolet B (UVB) radiation-induced DNA damage is a well-known initiator of skin carcinomas. The UVB-induced DNA damage response (DDR) involves series of signaling cascades that are activated to maintain cell integrity. Among the different biological processes, little is known about the role of energy metabolism in the DDR.
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