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dCasMINI-mediated therapy rescues photoreceptors degeneration in a mouse model of retinitis pigmentosa.
Sci Adv
December 2024
Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94304, USA.
Retinitis pigmentosa (RP) is characterized by degeneration of rod and cone photoreceptors that progresses to irreversible blindness. Now, there are no mutation-agnostic approaches to treat RP. Here, we utilized a single adeno-associated virus (AAV)-based CRISPR activation system to activate phosphodiesterase 6B (Pde6b) to mitigate the severe degeneration in mice.
View Article and Find Full Text PDFRefining Flash Visual Evoked Potential Analysis in Rats: A Novel Approach Using Bilateral Epidural Electrodes.
Transl Vis Sci Technol
December 2024
Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Purpose: Visual evoked potentials (VEPs) are electrical signals generated at the visual cortex following visual stimulation. Flash VEPs (fVEPs) are produced by global retinal stimulation and are considered an objective measure of the integrity of the entire visual pathway. However, fVEP measurements are highly sensitive to external variables, making relative comparisons of the fVEP waveforms between the two eyes in the same individual challenging.
View Article and Find Full Text PDFNormative Ranges for Oculomotor and Reaction Time Tests in U.S. Military Service Members and Veterans.
J Am Acad Audiol
May 2024
Audiology and Speech Pathology Center, Walter Reed National Military Medical Center, Bethesda, Maryland.
Background: Oculomotor and reaction time tests are frequently used assessments of vestibular symptoms, traumatic brain injury (TBI), or other neurological disorders in both clinical and research contexts. When interpreting these tests it is important to have a reference interval (RI) as a comparison for what constitutes a typical/expected response; however, the current body of research has only limited information regarding normative ranges calculated according to established standards or for a military-specific sample.
Purpose: The purpose of the present study was to describe RIs for oculomotor and reaction time tests in a cohort of service members and veterans (SMVs) for use as comparators by clinicians and scientists.
The Ercc1 mouse model of XFE progeroid syndrome undergoes accelerated retinal degeneration.
Aging Cell
November 2024
Institute on the Biology of Aging and Metabolism, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Age-related macular degeneration (AMD) is a major cause of vision loss in older adults. AMD is caused by degeneration in the macula of the retina. The retina is the highest oxygen consuming tissue in our body and is prone to oxidative damage.
View Article and Find Full Text PDFBlind But Alive - Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish.
Invest Ophthalmol Vis Sci
November 2024
Center for Regenerative Therapies at TU Dresden(CRTD), Dresden, Germany.
Article Synopsis
- The study focuses on adult zebrafish that are blind due to mutations in the atoh7 gene, which prevents the formation of retinal ganglion cells (RGCs).
- Researchers characterized the physical and behavioral traits of these mutants using various scientific techniques, noting distinct characteristics like dark pigmentation and reduced body size.
- The findings highlight that these adult zebrafish serve as a valuable model for studying conditions like glaucoma and optic nerve aplasia by providing insights into retinal and tectal structure.
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