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A p-n heterojunction sonosensitizer for improved sono-immunotherapy via induction of multimodal cell death mechanisms.
Theranostics
March 2025
Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200030, China.
Activating a robust immune system is a crucial strategy for combating solid tumors and preventing recurrences. Studies have shown that cuproptosis and the resulting increased reactive oxygen species (ROS) can trigger immunogenic cell death (ICD) and modulate the tumor immune microenvironment, thereby activating systemic immunity. Therefore, for this purpose, it is important to design a multifunctional copper-based nanomaterial.
View Article and Find Full Text PDFPhenylacetylcarbinol biotransformation by disrupted yeast cells using ultrasonic treatment in conjunction with a dipropylene glycol mediated biphasic emulsion system.
Sci Rep
March 2025
Center of Excellence, Agro-Bio-Circular-Green Industry (Agro-BCG) & Bioprocess Research Cluster (BRC), School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai, 50100, Thailand.
Biotransformation of a pharmaceutical precursor, phenylacetylcarbinol (PAC), could be achieved by frozen-thawed Candida tropicalis whole cells (FT-WHC). The treatment of FT-WHC, which contained intracellular pyruvate decarboxylase (PDC) enzyme, using high-power ultrasonication with varying amplitudes were compared with glass bead attrition (GBA) as well as control for the release of PDC. Ultrasonication at 20% amplitude (Ult20) proved to be the most effective, resulting in the highest volumetric and specific PDC activities of 0.
View Article and Find Full Text PDFInfluence of different airborne-particle abrasion pressures, cleaning methods, and artificial aging on zirconia ceramic bonding.
J Prosthet Dent
March 2025
Professor and Chairman, Department of Prosthodontics, Propaedeutics and Dental Materials, School of Dentistry, Christian-Albrechts University at Kiel, Kiel, Germany.
Statement Of Problem: Airborne-particle abrasion (APA) with alumina combined with a primer or luting resin containing a phosphate monomer has been well established for resin bonding to zirconia. However, a standardized method for bonding to zirconia is unavailable, as some factors including the optimal pressure of airborne-particle abrasion, the cleaning method, and the luting resin system are still unclear because of the limited available data.
Purpose: The purpose of this in vitro study was to evaluate the influence of different airborne-particle abrasion pressures and different cleaning methods of zirconia on the tensile bond strength (TBS) of 2 luting resins system containing methylacryloyloxydecyl-dihydrogenphosphate (MDP) either in the primer or in the luting resin.
Ultrasonic head-mounted device spatiotemporal opening blood-brain barrier enhances the brain permeation of drugs for treatment of radiation-induced brain injury.
Int J Pharm
March 2025
Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address:
The field of physical therapy is advancing and using focused ultrasound to deliver drugs into the brain gains growing interest. However, the blood-brain barrier makes it difficult for drugs to enter. Finding safe and efficient physical therapy strategies to complement drug treatments is essential.
View Article and Find Full Text PDFCemental tear, characterized by the separation of the cementum from the root surface of a tooth, is commonly observed in patients with localized periodontitis, particularly those with a complex medical history resulting in significant periodontal damage. This condition complicates both diagnosis and treatment, and cone beam computed tomography (CBCT) is a valuable tool for assessing the extent of damage and guiding treatment decisions. This report presents 3 clinical cases of cemental tear.
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