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Spontaneous recovery from neuromuscular block after a single dose of a muscle relaxant in pediatric patients: A systematic review using a network meta-analytic and meta-regression approach.
Paediatr Anaesth
August 2024
Department of Anesthesiology, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Background: Age-related differences in the pharmacokinetics and pharmacodynamics of neuromuscular blocking agents (NMBAs) and the short duration of many surgical procedures put pediatric patients at risk of postoperative residual curarization (PORC). To date, the duration of neuromuscular blocking agent effect in children has not been analyzed in a quantitative review. The current meta-analysis aimed to compare spontaneous recovery following administration of various types and doses of neuromuscular blocking agents and to quantify the effect of prognostic variables associated with the recovery time in pediatric patients.
View Article and Find Full Text PDF[How studies on curare contributed to the development of neurophysiological research in Brazil].
Biol Aujourdhui
November 2023
Laboratory of History of Psychiatry, Neurology, and Mental Health, Institute of Psychiatry Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brésil.
Curare is a poison obtained from different species of plants in South America, which was used in arrows by the natives. Its lethal paralyzing potential and mechanism of action began to be explored in the 19th century. In this article, we highlight the research on this poison and the fruitful exchanges between the Brazilian Emperor Dom Pedro II and the researchers João Baptista de Lacerda, Louis Couty and Alfred Vulpian who contributed to the development of experimental neurophysiology in Brazil.
View Article and Find Full Text PDFTranslatability of preclinical to early clinical tolerable and pharmacologically active dose ranges for central nervous system active drugs.
Transl Psychiatry
March 2023
Centre for Human Drug Research, Leiden, The Netherlands.
The primary purpose of this study was to assess the translatability of preclinical to early clinical tolerable and pharmacologically active dose ranges for central nervous system (CNS) active drugs. As a part of this, IBs were reviewed on reporting quality. Investigator's Brochures (IBs) of studies performed at the Centre for Human Drug Research (CHDR) reporting statistically significant results of CNS activity related to the drug's mechanism of action were included.
View Article and Find Full Text PDFCross-talk of cholinergic and β-adrenergic receptor signalling in chronic myeloid leukemia K562 cells.
Clin Exp Pharmacol Physiol
April 2022
Department of Biophysics, Marmara University, School of Medicine, Basic Medical Sciences Building, Istanbul, Turkey.
In many studies on breast, skin and intestinal cancers, β-adrenergic receptor antagonists have been shown to inhibit cell proliferation and angiogenesis and increase apoptosis in cancers. Carbachol inhibits chronic myeloid leukaemia K562 cell proliferation. Beta-blockers are known to inhibit cell progression.
View Article and Find Full Text PDFThe ischemic model of chronic muscle spasm and pain.
Eur J Transl Myol
January 2022
Interventional Health, PA, Lewes, DE.
This article was not intended to be a complete review of the electromyography of pathological muscle states, but it was written to illustrate how the "Coletti Method of EMG ChemoDenervation" (CMECD®) protocol for the treatment of chronic pain resulting from chronic muscle spasm was developed and established. That process led to an unexpected understanding of the underlying pathophysiology of chronic muscle spasm, which represents a paradigm shift in our understanding and ultimately in our treatment of muscle spasm-induced chronic pain. Other investigators had brought to light the presence of spontaneous electrical activity (SEA) in states of muscle spasm.
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