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Sex-specific cytokine, chemokine, and growth factor signatures in T1D patients and progressors.
FASEB J
December 2024
Biology Department, Boston College, Chestnut Hill, Massachusetts, USA.
Numerous studies have reported altered cytokine levels in type 1 diabetes (T1D) patients, yet findings remain inconsistent. In this pilot study, we tested the hypothesis that circulating immune markers exhibit sex-based differences in T1D, both prior to and after disease onset. We analyzed 47-48 cytokine, chemokine, and growth factor levels in two cohorts.
View Article and Find Full Text PDFBurnout is caused by long term psychosocial stress and has, besides the fatigue and mental health burden, been associated with increased risk of adverse physical health, such as for example type 2 diabetes. This study aims to investigate the glucose and insulin levels in individuals with stress related burnout, by assessing these metabolic markers in response to a standard oral glucose tolerance test (OGTT). 38 cases with burnout (13 men and 25 women) and 35 healthy controls (13 men and 22 women) in the age 24-55 were included in the study.
View Article and Find Full Text PDFFrom Dizziness to Dysphagia: A Complex Presentation of Lateral Medullary Syndrome.
Cureus
November 2024
Internal Medicine, AdventHealth New Smyrna Beach, New Smyrna Beach, USA.
Lateral medullary syndrome (LMS), also known as Wallenberg syndrome, is a rare neurological condition most commonly resulting from occlusion of the posterior inferior cerebellar artery (PICA). This syndrome is characterized by a constellation of symptoms including vertigo, ataxia, sensory deficits, and cranial nerve abnormalities, which arise due to infarction of the lateral medulla. We report the case of a 74-year-old female patient with a history of hypertension who presented to the emergency department with acute onset of vertigo and an unsteady gait.
View Article and Find Full Text PDFWallenberg Syndrome Secondary to Vertebrobasilar Aneurysm Associated With Subclavian Steal Syndrome.
Cureus
October 2024
Department of Neuroscience, Instituto Nacional de Cancerología, Mexico City, MEX.
Wallenberg syndrome, also known as lateral medullary syndrome, is a rare condition affecting the vertebrobasilar circulation, causing symptoms such as vertigo, nystagmus, dysarthria, and hemifacial weakness. Typically linked to ischemic strokes, it can also arise from vertebrobasilar aneurysms. In rare cases, subclavian steal syndrome (SSS), involving retrograde flow in the vertebral artery due to subclavian stenosis, complicates the picture, as observed in this case of a 66-year-old woman with both conditions and a vertebrobasilar aneurysm.
View Article and Find Full Text PDFRisk of Epilepsy Following a First Posttraumatic Seizure: A Register-Based Study.
Neurol Clin Pract
February 2025
Institute of Neuroscience and Physiology (MK, SH, JL, AS, JZ), Department of Clinical Neuroscience, Sahlgrenska Academy, Gothenburg University; Clinic of Neurology (MK, AS), Rehabilitation and Specialized Care at Home, Södra Älvsborg Hospital; Department of Research, Education and Innovation (MK, AS), Region Västra Götaland, Södra Älvsborg Hospital, Borås; Department of Neurology (SH, JZ), Sahlgrenska University Hospital; Wallenberg Center of Molecular and Translational Medicine (SH, JZ), Gothenburg University; and Department of Neurosurgery (JL), Sahlgrenska University Hospital, Gothenburg, Sweden.
Background And Objectives: Traumatic brain injury (TBI) is a common cause of epilepsy, and the risk increases with injury severity. Whether a first posttraumatic seizure (PTS) represents epilepsy is a common clinical problem, but often unknown. Prognostication is important for providing correct patient information and consideration of antiseizure medication.
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