Neuromuscular jitter was determined in the extensor digitorum communis (EDC) of 41 healthy control subjects and 8 patients with myasthenia gravis (MG). Standard single-fiber electromyographic (SFEMG) techniques were used, except that a monopolar electrode (MPE) was substituted for a single-fiber electrode (SFE). In normals, mean jitter for 20 pairs was 22.4 +/- 2.8 microseconds and the mean jitter for an individual pair was 22 +/- 5.6 microseconds. In the age range tested (18 to 49 years), jitter did not change with increasing age. When MPE jitter studies were repeated in 16 normals, mean jitter usually varied by less than 10% (mean 7.4% +/- 6.2%) and remained normal. Jitter was significantly increased in MG compared to normals 73 +/- 56 microseconds versus 22 +/- 5.6 microseconds (F = 149.4, P less than 0.0001). Using an analog pain scale, the discomfort during electromyography using MPE and SFE was compared between the left and right arms in 35 normals. MPEs caused less discomfort than SFEs (P = 0.0031), and were preferred (71% versus 20%) to SFEs (chi 2 = 9.21, P = 0.01). Based on these results, we conclude that MPE determined jitter studies are reproducible, can distinguish between normals and MG, and are associated with less discomfort than SFE.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mus.880150513 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Computational insights into the aggregation mechanism of human calcitonin.
Int J Biol Macromol
January 2025
School of Physical Science and Technology, Ningbo University, Ningbo 315211, China; Department of Physics and Astronomy, Clemson University, Clemson, SC 29634, United States. Electronic address:
Human calcitonin (hCT) is a peptide hormone that regulates calcium homeostasis, but its abnormal aggregation can disrupt physiological functions and increase the risk of medullary thyroid carcinoma. To elucidate the mechanisms underlying hCT aggregation, we investigated the self-assembly dynamics of hCT segments (hCT, hCT, and hCT) and the folding and dimerization of full-length hCT through microsecond atomistic discrete molecular dynamics (DMD) simulations. Our results revealed that hCT and hCT predominantly existed as isolated monomers with transient small-sized oligomers, indicating weak aggregation tendencies.
View Article and Find Full Text PDFElectron temperature measurement from neutral atomic tungsten emission line ratio.
Rev Sci Instrum
January 2025
University of Dayton Research Institute, Dayton, Ohio 45469, USA.
A method to determine electron temperature within a plasma by the spectral analysis of atomic tungsten emission has been explored. The technique was applied to a post-discharge region immediately following a high voltage nanosecond pulsed discharge in air with tungsten electrodes. Atomic tungsten lines are readily observed in the weak emission spectrum within the post-discharge region for many microseconds.
View Article and Find Full Text PDFA Multiscale Analysis of the CzrA Transcription Repressor Highlights the Allosteric Changes Induced by Metal Ion Binding.
J Phys Chem B
January 2025
Physics Department, University of Trento, Via Sommarive, 14, I-38123 Trento, Italy.
Allosteric regulation is a widespread strategy employed by several proteins to transduce chemical signals and perform biological functions. Metal sensor proteins are exemplary in this respect, e.g.
View Article and Find Full Text PDFUltra-low power-consumption OLEDs via phosphor-assisted thermally-activated-delayed-fluorescence-sensitized narrowband emission.
Nat Commun
January 2025
Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of Education, Department of Chemistry, Department of Chemistry, Tsinghua University, Beijing, China.
The further success of OLED beyond conventional low-luminance display applications has been hampered by the low power efficiency (PE) at high luminance. Here, we demonstrate the strategic implementation of an exceptionally high-PE, high-luminance OLED using a phosphor-assisted thermally-activated-delayed-fluorescence (TADF)-sensitized narrowband emission. On the basis of a TADF sensitizing-host possessing a fast reverse intersystem crossing, an anti-aggregation-caused-quenching character and a good bipolar charge-transporting ability, this design achieves not only a 100% exciton radiative consumption with decay times mainly in the sub-microsecond regime to mitigate exciton annihilations for nearly roll-off-free external quantum efficiency, but also narrowband emission with both small energetic loss during energy transfer and resistive loss with increasing luminance.
View Article and Find Full Text PDFDevelopment of a 300 kV/3 kHz nanosecond pulse generator using semiconductor opening switches.
Rev Sci Instrum
January 2025
State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.
In this paper, we present the development of a nanosecond pulse generator utilizing semiconductor opening switches (SOS), designed to deliver high voltage and operate at a high repetitive frequency. The pulse generator comprises three main components: a primary charging unit, a magnetic pulse compression unit, and an SOS magnification unit. To ensure stable operation of the high-power charging unit at high repetitive frequencies, a rectifying resonant charging and energy recovery circuit are implemented, providing a 1 kV charging voltage at a 3 kHz repetition rate.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!