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Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants.
Nat Commun
January 2025
Pfizer, Inc., Cambridge, MA, 02139, USA.
Several hydroxysteroid dehydrogenase 17-beta 13 variants have previously been identified as protective against metabolic dysfunction-associated steatohepatitis (MASH) fibrosis, ballooning and inflammation, and as such this target holds significant therapeutic potential. However, over 5 years later, the function of 17B-HSD13 remains unknown. Structure-aided design enables the development of potent and selective sulfonamide-based 17B-HSD13 inhibitors.
View Article and Find Full Text PDFUnveiling the Role of Electronic, Vibrational, and Optical Features of the 1T' WSe Monolayer.
ACS Omega
November 2024
Institute of Physics and International Center of Physics, University of Brasília, Brasília 70919-970, Federal District, Brazil.
Understanding the optoelectronic profile and chemical stability of transition-metal dichalcogenides (TMDs) is crucial for advancing two-dimensional (2D) material applications, particularly in electronics, optoelectronics, and energy devices. Here, we investigate the structural, electronic, optical, and excitonic properties of the 1T' WSe monolayer. Phonon dispersion analysis confirmed the thermodynamic stability of this system.
View Article and Find Full Text PDFDevelopment and feasibility of a sex- and gender-sensitive primary care intervention for patients with chronic non-cancer pain receiving long-term opioid therapy (GESCO): a study protocol.
Pilot Feasibility Stud
November 2024
Chair of Clinical Pharmacology, Faculty of Health, Witten/Herdecke University, Witten, Germany.
Background: Chronic non-cancer pain (CNCP) is a common condition worldwide. The disease burden is influenced not only by pain itself, but also by psychiatric co-morbidities, which aggravate symptoms, generally negatively influence therapies, and may thereby lead to frustration, resignation, or withdrawal. A growing body of evidence suggests that sex and gender aspects influence CNCP management as the experience of pain, the emotions associated with it, and the expression of pain may differ between women and men.
View Article and Find Full Text PDFDevice-Assisted Left Atrial Appendage Exclusion: From Basic Sciences to Clinical Applications.
J Cardiovasc Dev Dis
October 2024
Department of Pathophysiology, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, Poland.
Device-assisted left atrial appendage exclusion plays a crucial role in the prevention of fatal ischemic complications in patients with atrial fibrillation and contraindications to anticoagulation treatment. Various devices with different safety profiles and device-related complications are available in daily practice to perform this procedure. In this review, the anatomy, physiology, and functions of the left atrial appendage were detailed, and all available devices used for epicardial and endocardial exclusion of the left atrial appendage and their clinical outcomes were discussed.
View Article and Find Full Text PDFThe paper explores the development of psychotherapy in Polish psychiatry in the interwar period from the perspective of Kurt Danziger's historical psychology. Firstly, the organizational and social context of the development of Polish psychiatric care in the interwar period and its impact on the development of psychotherapy is outlined. Then, the most influential in Poland, European psychotherapeutic developments in the interwar period are reconstructed.
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