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Alzheimers Dement
December 2024
Center for Life Ethics, University of Bonn, Bonn, Germany.
Background: In recent years, research on risk estimation and early detection of Alzheimer's disease (AD) advanced swiftly. Studies are investigating the likelihood of developing Alzheimer's dementia (ADD), even during asymptomatic, preclinical, and prodromal stages of AD. Particular hope is pinned on blood-based biomarkers as these are less invasive than other methods such as lumbar puncture and Positron Emission Tomography (PET)-scan.
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Alzheimers Dement
December 2024
Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, GIP Cyceron, Caen, France.
Background: Despite evidence that sex can modulate Alzheimer's disease (AD) risk, whether risk factors are similarly related to AD markers in women and men remains largely unexplored. We aimed to assess how a combination of potentially modifiable risk factors are associated with cognitive and pathological markers of AD in older women and men.
Method: We included 135 cognitively unimpaired older adults (≥65 years old, 83 women; Table 1) from the Age-Well trial (NCT02977819; baseline data) with multidomain assessments of modifiable risk factors, including cardiovascular (body mass index, systolic blood pressure, LDL cholesterol), lifestyle (complex mental activity throughout life, physical activity, diet), and psychological (quality of life, depressive and anxiety symptoms, rumination, worry).
Biomarkers.
Alzheimers Dement
December 2024
Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Korea, Republic of (South).
Background: Changes in brain network organization are influenced by aging. Accumulation of amyloid-beta (Aβ) and neurodegeneration in the neocortex are also expected to alter neuronal networks. Therefore, we examined the relationship between aging and brain functional connectivity (FC), as well as the effect of brain Aβ on this relationship.
View Article and Find Full Text PDFBackground: Down syndrome (DS, trisomy 21) is the most frequent genetic cause of intellectual disability (ID), prevalent in approximately 1 in 900 live births (Loane et al., 2013). People with DS are at high risk to develop Alzheimer's disease dementia (AD) (Lott & Head, 2001).
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