Dysgenesia of the ovaries was produced by the destruction of the germinal cells during the foetal life by injecting the pregnant rat with Misulban. In the absence of ovocytes, follicular organization did not take place and cordal structure were observed in the ovary. The post-puberal evolution of these gonads led to polymorphous structures according to age and individual cases. Study of dysgenesic ovaries of rats treated by stilboestrol before puberty, showed mainly that the ovarian stroma was affected in response to the inhibition of the pituitary gonadotropic activity. It is concluded that the development of these ovaries is under the control of the hypothalamo=pituitary axis.
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Establishment of the reproductive function and transient fertility of female rats lacking primordial follicle stock after fetal gamma-irradiation.
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Laboratoire de Physiologie et Physiopathologie, Centre National de la Recherche Scientifique-UMR 7079, Université Paris VI, Paris, France.
In mammals, the primordial follicle stock is not renewable, and its size, therefore, limits the reproductive life span of the female. In this study we have investigated the morphological and functional differentiation of dysgenesic ovaries in female rats exposed in utero to 1.5 Gy gamma-irradiation.
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