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T Cells Induce Prolonged Downregulation of Barrier Molecules in a Mouse Model of Allergic Contact Dermatitis.
Allergy
December 2024
The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Background: Dysfunction of the skin barrier is regarded as a key event in the initiation and progression of inflammatory skin diseases. In many cases of allergic contact dermatitis (ACD), epidermal-resident memory CD8 T (T) cells play a central role in the immune response to contact allergens. However, if and how allergen-specific CD8 T cells affect the expression of skin barrier molecules is not known.
View Article and Find Full Text PDFIncorporating immune cell surrogates into a full-thickness tissue equivalent of human skin to characterize dendritic cell activation.
Sci Rep
December 2024
Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Universitätsstr.1, 40225, Düsseldorf, Germany.
Article Synopsis
- Research on dendritic cell (DC) activation has mostly relied on animal models, highlighting the need for human-based in vitro models due to differences in DC types across species.
- Scientists have created a full-thickness human skin tissue model with Langerhans cell (LC) and dermal dendritic cell (DDC) surrogates from human leukemia cell lines to study their activation.
- When exposed to nickel sulfate or DNCB, the model showed significant increases in CD1a positive cells, indicating that these treatments trigger a response leading to DC migration and activation within a short time frame.
Spontaneous reversal of small molecule-induced mitochondrial uncoupling: the case of anilinothiophenes.
FEBS J
December 2024
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Russia.
Tissue specificity can render mitochondrial uncouplers more promising as leading compounds for creating drugs against serious diseases. In search of tissue-specific uncouplers, we address anilinothiophenes as possible glutathione-S-transferase substrates (GST). Earlier, 'cyclic' uncoupling activity was reported for 5-bromo-N-(4-chlorophenyl)-3,4-dinitro-2-thiophenamine (BDCT) in isolated rat liver mitochondria (RLM).
View Article and Find Full Text PDFA near-infrared fluorescent probe with a large Stokes shift for the detection and imaging of biothiols in vitro and in vivo.
Anal Bioanal Chem
November 2024
Hubei Key Laboratory for Precision Synthesis of Small Molecule Pharmaceuticals & Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan, 430062, People's Republic of China.
In this study, a new near-infrared (NIR) fluorescent turn-on probe featuring a large Stokes shift (198 nm) was developed for the detection of biothiols. The probe was based on a dicyanoisophorone derivative serving as the fluorophore and a 2,4-dinitrobenzenesulfonyl (DNBS) group functioning as both a recognition site and a fluorescence quencher. In the absence of biothiols, the fluorescence of the probe was low due to the photoinduced electron transfer (PET) effect between the fluorophore and DNBS.
View Article and Find Full Text PDFFerrostatin-1 alleviates skin inflammation and inhibits ferroptosis of neutrophils and CD8 T cells in allergic contact dermatitis.
J Dermatol Sci
October 2024
Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China. Electronic address:
Article Synopsis
- Ferroptosis is highlighted as a type of cell death linked to inflammatory skin conditions, but its role in allergic contact dermatitis (ACD) is not well understood.
- The study aimed to understand how ferroptosis contributes to ACD using a mouse model, focusing on different cell types and employing a treatment to inhibit this process.
- Results showed that ferroptosis was particularly significant in immune cells like neutrophils and CD8 T cells, and using a ferroptosis inhibitor improved skin inflammation and reduced cell death in ACD mice.
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