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The Effect of Isoniazid for Tuberculosis Prevention on Pregnancy Risk Among Women Living With HIV on Antiretroviral Treatment and Progestin-Based Hormonal Contraception.
Pharmacoepidemiol Drug Saf
February 2025
UNC Project-Malawi, Lilongwe, Malawi.
Purpose: Concomitant use of antiretroviral therapy (ART), hormonal contraception, and isonicotinic acid hydrazide (isoniazid) for tuberculosis prevention is common among women of reproductive age who are living with HIV in sub-Saharan Africa. We estimated the effect of isoniazid on 6-month pregnancy risk among Malawian women living with HIV in the Family Planning and Antiretroviral Therapy (FP-ART) prospective cohort study, overall and among subgroups defined by ART regimen type and hormonal contraceptive method.
Methods: The analytic sample included visits contributed by participants who were currently using either efavirenz- or dolutegravir-based ART and either depot medroxyprogesterone acetate (DMPA) or levonorgestrel (LNG) implant contraception at the time of the visit.
Synthesis and Evaluation of Cytotoxic Activity of RuCp(II) Complexes Bearing (Iso)nicotinic Acid Based Ligands.
Pharmaceuticals (Basel)
January 2025
Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.
Background/objectives: Cancer remains one of the major challenges of our century. Organometallic ruthenium complexes are gaining recognition as a highly promising group of compounds in the development of cancer treatments.
Methods: Building on the auspicious results obtained for [Ru(η-CH)(PPh)(bipy)][CFSO] (TM34), our focus has shifted to examining the effects of incorporating bioactive ligands into the TM34 framework, particularly within the cyclopentadienyl ring.
An Adaptive Metal-Organic Framework Discriminates Xylene Isomers by Shape-Responsive Deformation.
Adv Mater
December 2024
Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
The separation of xylene isomers, especially para-xylene, is a crucial but challenging process in the chemical industry due to their similar molecular dimensions. Here, a flexible metal-organic framework, Ni(ina), (ina = isonicotinic acid) is employed to effectively discriminate xylene isomers. The adsorbent with adaptive deformation accommodates the shapes of isomer molecules, thereby translating their subtle shape differences into characteristic framework deformation energies.
View Article and Find Full Text PDFThermal Bistability of Magnetic Susceptibility, Light Absorption, Second Harmonic Generation, and Dielectric Properties in a Polar Spin-Crossover Iron-Rhenium Chain Material.
Angew Chem Int Ed Engl
November 2024
Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Kraków, Poland.
The bistability of multiple physical properties driven by external stimuli in a solid is a desired prerequisite for its application in memory devices with convenient data readout. We present a pathway for thermal bistability detectable in four physical properties: magnetic, light absorption, second-harmonic generation (SHG), and dielectric. We report a novel heterometallic (TBA){[Fe(phIN)][Re(CN)]} ⋅ (phIN) (1) (TBA=tetrabutylammonium cation, phIN=phenyl isonicotinate) cyanido-bridged chain material.
View Article and Find Full Text PDFRole of the Kölliker-Fuse/parabrachial complex in the generation of postinspiratory vagal and sympathetic nerve activities and their recruitment by hypoxemic stimuli in the rat.
J Neurophysiol
November 2024
Macquarie Medical School, Faculty of Medicine, Health and Human SciencesMacquarie University, Sydney, Australia.
Article Synopsis
- The study investigates how the Kölliker-Fuse/Parabrachial nuclei (KF-PBN) in rats regulates post-inspiratory (post-I) activities that affect respiratory efficiency during normal conditions and acute hypoxemia.
- When the KF-PBN was inhibited, researchers observed changes such as reduced phrenic nerve activity and abolished post-I vagal responses, indicating its role in managing these respiratory outputs.
- The findings suggest the KF-PBN is crucial for modulating post-I vagal activity but only partially involved in sympathetic nerve activity, implying multiple neural pathways are at play in respiratory-sympathetic coordination during stress.
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