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ARF6 as a Novel Activator of HIF-2α in Pulmonary Arterial Hypertension.
Am J Respir Cell Mol Biol
November 2024
Imperial College London, London, United Kingdom of Great Britain and Northern Ireland.
Article Synopsis
- ARF6, a GTPase linked to cancer metastasis, is activated in lung endothelial cells during pulmonary arterial hypertension (PAH) and influences several key biological pathways.
- Proteomic analysis of human pulmonary artery endothelial cells revealed that active ARF6 is associated with increased expression of hypoxia-inducible factor (HIF-2), essential for PAH, while showing lesser impact on HIF-1.
- A novel ARF6 inhibitor, chlortetracycline (CTC), demonstrated potential in reducing HIF-2 activation and mitigating symptoms of PAH, indicating a new therapeutic approach that may target this pathway for better management of the disease.
Chronic nonspecific cheilitis associated with tislelizumab treatment in a patient with a history of tongue squamous cell carcinoma: a case report.
BMC Oral Health
August 2024
Stomatological Hospital, School of Stomatology, Southern Medical University, 366# Southern Jiangnan Road, Guangzhou, Guangdong, 510280, China.
Article Synopsis
- Chronic nonspecific cheilitis is a condition causing persistent lip peeling and discomfort, particularly studied in a patient with a history of tongue squamous cell carcinoma treated with Tislelizumab.
- The patient experienced six months of lip peeling, and upon examination, was diagnosed with chronic nonspecific cheilitis and infectious angular cheilitis, leading to a personalized treatment plan involving oral hygiene and topical medications.
- The case highlights the need for tailored treatment in cancer patients receiving immunotherapy, showing that a comprehensive approach can improve symptoms and emphasize the importance of regular follow-ups for patient health.
Impact of In-Feed versus In-Water Chlortetracycline and Tiamulin Administrations on Fecal Prevalence and Antimicrobial Susceptibilities of in a Population of Nursery Pigs.
Microorganisms
November 2023
Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Antimicrobial resistance (AMR) in bacteria is a major public health concern in the US and around the world. is an important foodborne pathogen that resides in the gut of pigs and is shed in feces, with the potential to be transmitted to humans. In pigs, the oral route, either in-feed or in-water, is by far the most common route of administration of antimicrobials.
View Article and Find Full Text PDFRescue of Dopamine Neurons from Iron-Dependent Ferroptosis by Doxycycline and Demeclocycline and Their Non-Antibiotic Derivatives.
Antioxidants (Basel)
February 2023
Paris Brain Institute-ICM, Inserm, Sorbonne Université, CNRS, Hôpital Pitié Salpêtrière, 75013 Paris, France.
Several studies have reported that the tetracycline (TC) class antibiotic doxycycline () is effective against Parkinson's disease (PD) pathomechanisms. The aim of the present work was three-fold: (i) Establish a model system to better characterize neuroprotection by ; (ii) Compare the rescue effect of to that of other TC antibiotics; (iii) Discover novel neuroprotective TCs having reduced antibiotic activity. For that, we used cultures of mouse midbrain dopamine (DA) neurons and experimental conditions that model iron-mediated oxidative damage, a key mechanism in PD pathobiology.
View Article and Find Full Text PDFBioavailability of tetracyclines is substantially increased by administration of cyclosporine A, a non-specific efflux-pump blocker.
Drug Metab Pharmacokinet
June 2023
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718, Olsztyn, Poland. Electronic address:
Objectives: To investigate how cyclosporine A, a nonspecific efflux-pump blocker, affects the plasma concentrations and oral bioavailability of tigecycline, oxytetracycline, chlortetracycline, doxycycline, minocycline, and tetracycline.
Methods: Broiler chickens were used as an animal model. The tetracyclines (10 mg/kg BW) were administered intravenously, orally, and orally with cyclosporine A (50 mg/kg BW; administration: oral or intravenous).
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