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A real-world pharmacovigilance analysis of potential ototoxicity associated with sacubitril/valsartan based on FDA Adverse Event Reporting System (FAERS).

Sci Rep

December 2024

Department of Comprehensive Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Sacubitril/valsartan, a first-in-class angiotensin receptor neprilysin inhibitor, is widely used to treat heart failure. Despite its efficacy, sacubitril/valsartan inevitably causes adverse events such as hypotension, renal dysfunction, hyperkalemia, and angioedema. Sacubitril/valsartan-associated ototoxicity is often underreported in clinical studies and real-world settings.

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Piezoelectric materials are increasingly used in portable smart electronics and Internet of Things sensors. Among them, piezoelectric macro fiber composites (MFCs) have attracted much attention due to their architectural simplicity, scalability, and high-power density. However, most MFCs currently use toxic lead-based piezoelectric materials, hindering their applications for bio-friendly intelligent electronics.

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