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Platelet-mimicking nanoparticles loaded with diallyl trisulfide for Mitigating Myocardial Ischemia-Reperfusion Injury in rats.
Colloids Surf B Biointerfaces
April 2025
Department of Ultrasonography, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:
Hydrogen sulfide (HS) shows promise in treating myocardial ischemia-reperfusion injury (MIRI), but the challenge of controlled and sustained release hinders its clinical utility. In this study, we developed a platelet membrane-encapsulated mesoporous silica nanoparticle loaded with the HS donor diallyl trisulfide (PM-MSN-DATS). PM-MSN-DATS demonstrated optimal encapsulation efficiency and drug-loading content.
View Article and Find Full Text PDFDiallyl Disulfide Mitigates Cadmium Hepatotoxicity by Attenuating Oxidative Stress and TLR-4/NF-κB Signaling and Upregulating PPARγ.
Front Biosci (Landmark Ed)
October 2024
Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, M1 5GD Manchester, UK.
Background: Heavy metals can cause serious health problems that affect different organs. Cadmium (Cd) is an environmental contaminant known for its toxicological consequences on different organs. Hepatotoxicity is a serious effect of exposure to Cd with oxidative stress (OS) and inflammation playing a central role.
View Article and Find Full Text PDFDiallyl disulfide alleviates hepatic steatosis by the conservative mechanism from fish to tetrapod: Augment Mfn2/Atgl-Mediated lipid droplet-mitochondria coupling.
Redox Biol
November 2024
Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan, 430070, China. Electronic address:
Despite increasing evidences has highlighted the importance of mitochondria-lipid droplet (LD) coupling in maintaining lipid homeostasis, little progress in unraveling the role of mitochondria-LD coupling in hepatic lipid metabolism has been made. Additionally, diallyl disulfide (DADS), a garlic organosulfur compound, has been proposed to prevent hepatic steatosis; however, no studies have focused on the molecular mechanism to date. To address these gaps, this study investigated the systemic control mechanisms of mitochondria-LD coupling regulating hepatic lipid metabolism, and also explored their function in the process of DADS alleviating hepatic steatosis.
View Article and Find Full Text PDFActive-bromide and surfactant synergy for enhanced microfouling control.
Arch Microbiol
October 2024
Water & Steam Chemistry Division, Bhabha Atomic Research Centre Facilities, Kalpakkam, 603102, India.
Article Synopsis
- Biofilms, which are structured communities of microbes, create problems in industrial cooling systems, especially in nuclear power plants, where active-bromide is used as a biocide to control biological growth.
- A study found that active-bromide at 1 ppm had minimal effectiveness against certain bacteria, and while higher concentrations showed better results, combining it with the surfactant Triton-X 100 significantly improved biofilm control.
- The research suggests that using a surfactant alongside active-bromide can enhance its effectiveness against established biofilms, indicating that a dual approach may be necessary for better microfouling control in seawater cooling systems.
Triton X-100-treated virus-based ELLA demonstrates discordant antigenic evolution of influenza B virus hemagglutinin and neuraminidase.
J Virol
October 2024
Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
Neuraminidase (NA)-specific antibodies have been associated with protection against influenza and thus NA is considered a promising target for next-generation vaccines against influenza A (IAV) and B viruses (IBV). NA inhibition (NI) by antibodies is typically assessed using an enzyme-linked lectin assay (ELLA). However, ELLA can be confounded by anti-hemagglutinin (anti-HA) antibodies that block NA by steric hindrance (termed HA interference).
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