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BAMLET administration via drinking water inhibits intestinal tumor development and promotes long-term health.
Sci Rep
February 2024
Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Faculty of Medicine, Lund University, Klinikgatan 28, 221 84, Lund, Sweden.
Though new targeted therapies for colorectal cancer, which progresses from local intestinal tumors to metastatic disease, are being developed, tumor specificity remains an important problem, and side effects a major concern. Here, we show that the protein-fatty acid complex BAMLET (bovine alpha-lactalbumin made lethal to tumor cells) can act as a peroral treatment for colorectal cancer. Apc mice, which carry mutations relevant to hereditary and sporadic human colorectal cancer, that received BAMLET in the drinking water showed long-term protection against tumor development and decreased expression of tumor growth-, migration-, metastasis- and angiogenesis-related genes.
View Article and Find Full Text PDFMajocchi's Granuloma - The Great Mimicker: A Case Report.
Case Rep Dermatol
October 2023
Skin Clinic, Kolding, Denmark.
Article Synopsis
- Fungal infections, often mistaken for conditions like eczema or psoriasis, can be difficult to identify and might be improperly treated with topical corticosteroids, leading to a condition called tinea incognita.
- A 54-year-old man experienced a painful rash in the genitoinguinal area that was initially treated unsuccessfully with various topical antifungals and antibiotics.
- Ultimately diagnosed with Majocchi's granuloma after thorough examination and histopathology, the patient successfully improved with a 16-week course of itraconazole, highlighting the need for awareness of such infections among non-specialist doctors.
Disseminated infection in a patient with a history of sarcoidosis.
BMJ Case Rep
May 2023
Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus N, Denmark.
We present a case of infection in a man in his 60s with a history of sarcoidosis, treated for 24 years with systemic corticosteroids and later methotrexate as monotherapy. He presented with low grade fever, dyspnoea and right-sided thoracic pain and was admitted due to a treatment-refractory infection. After a prolonged period of symptoms and diagnostics, acid-fast bacilli were demonstrated in pleural fluid and PCR revealed The patient was treated with intravenous amikacin, peroral azithromycin, rifampicin and ethambutol for a total of 18 months, with a good clinical and radiological treatment response.
View Article and Find Full Text PDFNovel Per-Oral Cricopharyngotomy for Cricopharyngeal Bar: Feasibility Study With Emphasis on Technical Limitations.
Cureus
March 2023
Department of Surgery, University of South Florida Morsani College of Medicine, Tampa, USA.
Per-oral endoscopic cricopharyngotomy (c-POEM) is a treatment for cricopharyngeal dysfunction, specifically cricopharyngeal bars (CPB). C-POEM differs from other endoscopic surgical procedures, such as per-oral endoscopic myotomy (POEM), gastric per-oral endoscopic myotomy (g-POEM), and Zenker per-oral endoscopic myotomy (z-POEM). We report three patients who underwent c-POEM for CPB, their clinical course, and outcomes.
View Article and Find Full Text PDFUnexpected delayed reversal of rocuronium-induced neuromuscular blockade by sugammadex: A case report and review of literature.
World J Clin Cases
December 2022
Department of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 220, Taiwan.
Background: Rocuronium, a nondepolarizing muscle relaxant, is usually administered during general anesthesia to facilitate endotracheal intubation and keep patients immobile during the surgery. Sugammadex, the selective reversal agent of rocuronium, fully reverses the neuromuscular blockade (NMB) at the end of surgery. Most reports show that sugammadex rapidly achieves a ratio of train-of-four (TOF), a quantitative method of neuromuscular monitoring, of 0.
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