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Calcium Acetate Drug Produced from Invasive Gastropod Shells: Green Process Control Assisted by Raman Technology.
ACS Omega
September 2024
Ioan Ursu Institute of the Faculty of Physics, Babeş-Bolyai University, 1 Kogălniceanu, 400084 Cluj-Napoca, Romania.
The highly demanded calcium acetate (Ca(CHCOO)) for biomedicine and various industries constantly requires green and low-cost methods of synthesis. In the present work, a sustainable approach to produce Ca(CHCOO) is reported as a proof of concept, processing for the first time as a starting material the worldwide highly abundant shells, which is a neglected biogenic waste with high economical potential due to the rich mineral and organic pigmentary content. A green synthesis involving an eco-friendly acetic acid has been optimized at room temperature, without any additional energy consumption, and the resulting saturated Ca(CHCOO) solution was further slowly evaporated in three stages to obtain white Ca(CHCOO) crystalline powder, without impurity traces.
View Article and Find Full Text PDFPreclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment.
Sci Rep
July 2023
Neurocarrus Inc, Monterey, CA, USA.
Inhibition of actin remodeling in nerves modulates action potential propagation and therefore could be used to treat acute pain. N-001 is a novel protein analgesic engineered from several C. Botulinum toxins.
View Article and Find Full Text PDFMn-SOD alleviates methotrexate-related hepatocellular injury via GSK-3β affecting anti-oxidative stress of HO-1 and Drp1.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
September 2022
Department of Infectious Diseases, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Objectives: Methotrexate (MTX) is the most common therapeutic agent that may have the risk of drug-induced liver injury. Its pathogenic mechanism is related to oxidative stress caused by mitochondrial dysfunction. Superoxide dismutase (SOD), including manganese-containing SOD (Mn-SOD), can exert its effect of anti-oxidative stress by scavenging superoxide free radicals.
View Article and Find Full Text PDFRemdesivir in treating hospitalized patients with COVID-19: A renewed review of clinical trials.
Front Pharmacol
September 2022
Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
Since December 2019, COVID-19 has spread across the world almost through 2.5 years. As of 16 June 2022, the cumulative number of confirmed cases of COVID-19 worldwide has reached 542.
View Article and Find Full Text PDFNemvaleukin alfa, an engineered cytokine that may induce the tumor-fighting benefits of IL2 without the side effects, has demonstrated effectiveness against solid tumors. As a monotherapy, the drug produced overall response rates of 13% in patients with advanced melanoma and 18.2% in advanced renal cell carcinoma.
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