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Potential of mesenchymal stromal/stem cells and spermatogonial stem cells for survival and colonization in bull recipient testes after allogenic transplantation.
Theriogenology
December 2024
Faculty of Veterinary and Animal Sciences, University of Chile, Santa Rosa 11735, 8820808, Santiago, Chile; Escuela de Medicina Veterinaria, Facultad de Agronomía e Ingeniería Forestal, Facultad de Ciencias Biológicas y Facultad de Medicina, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Macul, 7820436, Santiago, Chile. Electronic address:
Stem cell transplantation into seminiferous tubules of recipient testis could become a tool for fertility restoration, genetic improvement, or conservation of endangered species. Spermatogonial stem cells (SSCs) are primary candidates for transplantation; however, limited abundance, complexity for isolation and culture, and lack of specific markers have limited their use. Mesenchymal stromal/stem cells (MSCs) are multipotent progenitors that are simple to isolate and culture and possess specific markers for identification, and immune evasive and migratory capacities.
View Article and Find Full Text PDFMetabolic Stability and Metabolite Identification of CYP450 Probe Substrates in Ferret Hepatocytes.
Curr Drug Metab
September 2024
Shanghai Bioduro Biologics Co., Ltd, China.
Background: Ferrets exhibit similar lung physiology to humans and display similar clinical signs following influenza infection, making them a valuable model for studying high susceptibility and infection patterns. However, the metabolic fate of several common human CYP450 probe substrates in ferrets is still unknown and has not been studied.
Objective: The purpose of this study was to investigate the metabolism of nine human CYP450 probe substrates in ferret hepatocytes and explore their metabolic rate differences between ferrets and other species.
Background: Blood collection from donors on testosterone therapy (TT) is restricted to red blood cell (RBC) concentrates to avoid patient exposure to supraphysiological testosterone (T). The objective of this study was to identify TT-related changes in RBC characteristics relevant to transfusion effectiveness in patients.
Study Design: This was a two-part study with cohorts of patients and blood donors on TT.
Androgen and glucocorticoid profiles throughout extended uniparental paternal care in the eastern hellbender salamander (Cryptobranchus a. alleganiensis).
Gen Comp Endocrinol
September 2024
Virginia Tech, Department of Fish and Wildlife Conservation, Blacksburg, VA 24060, USA.
The behavioral endocrinology associated with reproduction and uniparental male care has been studied in teleosts, but little is known about hormonal correlates of uniparental male care in other ectotherms. To address this gap, we are the first to document the seasonal steroid endocrinology of uniparental male hellbender salamanders during the transition from pre-breeding to nest initiation, and through the subsequent eight months of paternal care. In doing so, we investigated the correlates of nest fate and clutch size, exploring hellbenders' alignment with several endocrinological patterns observed in uniparental male fish.
View Article and Find Full Text PDFLoss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility.
Cell Mol Life Sci
May 2024
Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, 810001, Qinghai, China.
Article Synopsis
- Leydig cells are crucial for testosterone production and male fertility, and their dysfunction can lead to serious reproductive issues.
- The transcription factor PBX1 has been identified as a key regulator of Leydig cell differentiation and testosterone synthesis in mouse models.
- Deleting Pbx1 in Leydig cells results in infertility, structural damage to testicular tissue, and altered hormone levels, particularly causing a drop in testosterone while increasing other hormones.
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