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Decoding Beta-Lactam Cross-Reactivity - Longitudinal Patch Testing From 2000 to 2022.
Contact Dermatitis
March 2025
Dermatology, University Hospital, Coimbra Local Health Unit, Coimbra, Portugal.
Introduction: Patients with non-immediate hypersensitivity to beta-lactam antibiotics (βL) often avoid all βL, with limitations for future therapy.
Objectives: Assess cross-reactivity between βL in non-immediate cutaneous adverse drug reactions (ni-CADRs).
Methods: Retrospective analysis (2000-2022) of patients with suspected ni-CADR with βL as a possible culprit who underwent patch testing (PT) with an extended antibiotic series (10% pet.
Exploring Associations Between Social Factors and Current Substance Use Among Older African Americans with HIV.
Subst Use Misuse
March 2025
Department of Population and Public Health Sciences, Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA.
Background: Substance use is highly prevalent among older people with HIV and continues to have a negative impact on engagement along the HIV care continuum, particularly among African Americans (AA). Social factors like resource insecurity, stigma, and discrimination may play a role in substance use behaviors. However, there is limited research on how these social factors impact substance use among older people with HIV.
View Article and Find Full Text PDFBackground: Actinic keratosis (AK) frequently manifests as multiple regional lesions on the exposed areas of the face and scalp. The simultaneous treatment of extensive lesions with varying degrees poses a significant challenge.
Objective: This study evaluated the efficacy and patient satisfaction of 5-aminolevulinic acid (5-ALA) photodynamic therapy (PDT) combined with curettage in managing extensive AK on the face and scalp.
Long-term follow-up after ureteral reimplantation in children: a 12-year analysis.
Pediatr Surg Int
March 2025
Division of Pediatric Urology, University Children's Hospital Zurich, Zurich, Switzerland.
Purpose: To evaluate the incidence of late surgical complications and long-term kidney outcomes following ureteral reimplantation (UR) for high-grade vesicoureteral reflux (VUR) and primary obstructed megaureter (POM), assessing the necessity of routine long-term follow-up.
Methods: A retrospective review was conducted of 135 children who underwent UR between 2006 and 2013, with at least 10 years of follow-up. Primary outcomes included postoperative ureterovesical junction obstruction (pUVJO) and febrile urinary tract infections (UTIs).
A single-dose, four-cycle, fully repetitive crossover bioequivalence of dabigatran etexilate in Chinese.
BMC Pharmacol Toxicol
March 2025
School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China.
Purpose: Among healthy Chinese subjects, two capsules of dabigatran etexilate were tested for bioequivalence.
Method: Fifty healthy subjects were recruited for each of the fasting and postprandial trials in a randomized, two-sequence, open-label, four-cycle, fully replicated trial design of a single 150 mg dose of either the test or the reference formulation of dabigatran etexilate capsules in the fasting and postprandial states. The blood concentration of dabigatran at different time points after administration was determined by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).
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