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Estimation of the Harvey Bradshaw Index from the Patient-Reported Outcome 2 in Crohn's Disease: Results Based on a Large Scale Randomized Controlled Trial.
Inflamm Bowel Dis
December 2024
Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
Background: Many registrational trials in Crohn's disease assess treatment efficacy with the 2-item Patient-Reported Outcome (PRO2), while the Harvey-Bradshaw Index (HBI) is prominent in pragmatic trials and clinical practice. The translation between PRO2 and HBI has not been established.
Methods: Data from a Phase 3 trial of vedolizumab in Crohn's disease were used to determine the Pearson correlation between PRO2 and HBI.
Promoting healthy practices among schools and children in rural bangladesh: a randomised controlled trial of skill-based health education.
BMC Public Health
November 2024
Maternal & Child Wasting Project, Result for Development (USA), Dhaka, Bangladesh.
Background: Poor child health and hygiene practices are persistent issues in resource-constrained settings, particularly in low-income countries. This study assessed the impact of skill-based health education (SBHE) on school and child hygiene practices in rural Bangladesh.
Methods: A cluster-randomised-controlled intervention with cross-cutting/factorial design was conducted in 180 randomly selected primary schools, stratified by school type, in Jhenaidah District, Bangladesh.
Poorly Recognized and Uncommonly Acknowledged Limitations of Randomized Controlled Trials.
Indian J Psychol Med
November 2024
Dept. of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Randomized controlled trials (RCTs) are a gold standard in evidence-based research. However, RCTs have limitations, among which the most commonly acknowledged is that narrow study selection criteria compromise the external validity of the findings. This article briefly touches upon this and other well-recognized limitations and presents, in greater detail, less commonly acknowledged limitations with examples from contemporary literature.
View Article and Find Full Text PDFEmergence of planar cell polarity from the interplay of local interactions and global gradients.
Elife
October 2024
Department of Biomedical Engineering, Indian Institute of Technology, Hyderabad, India.
Article Synopsis
- Planar cell polarity (PCP) is crucial for proper embryonic development and functions, with disturbances leading to issues like neural tube defects and hair follicle misalignment.
- The study explores how PCP is established and maintained, highlighting the roles of both global tissue-level gradients and local protein distribution, which have been previously under-examined.
- A minimal model was created that shows PCP can develop without a gradient, but having one enhances stability and resilience against random fluctuations, while simultaneously explaining observed patterns using just three key parameters.
Recent progress in DNA data storage based on high-throughput DNA synthesis.
Biomed Eng Lett
September 2024
Department of Biomedical Engineering, Korea University, 466 Hana Science Hall, Seoul, 02841 Korea.
DNA data storage has emerged as a solution for storing massive volumes of data by utilizing nucleic acids as a digital information medium. DNA offers exceptionally high storage density, long durability, and low maintenance costs compared to conventional storage media such as flash memory and hard disk drives. DNA data storage consists of the following steps: encoding, DNA synthesis (i.
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