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Small but mighty: targeted antifungal liposomes of a smaller size are superior in treating cryptococcal meningitis.
mBio
December 2024
Department of Plant Biology, University of Georgia, Athens, Georgia, USA.
Unlabelled: Cryptococcal meningoencephalitis (CME) is deadly. CME is responsible for 19% of deaths in AIDS patients, and its global mortality is greater than 60%. The recommended CME therapy requires amphotericin B (AmB), a fungicidal drug targeting fungal ergosterol.
View Article and Find Full Text PDFSuccessful strategies for expression and purification of ABC transporters.
Biochim Biophys Acta Biomembr
February 2025
Department and Chemistry and Molecular Biology, Gothenburg University, Box 462, 405 30 Göteborg, Sweden. Electronic address:
ATP-binding cassette (ABC) transporters are proteins responsible for active transport of various compounds, from small ions to macromolecules, across membranes. Proteins from this superfamily also pump drugs out of the cell resulting in multidrug resistance. Based on the cellular functions of ABC-transporters they are commonly associated with diseases like cancer and cystic fibrosis.
View Article and Find Full Text PDFFolate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers.
Mol Cancer
October 2024
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Article Synopsis
- Chitosan nanoparticles (NPs) are effective for delivering anticancer drugs by enhancing their solubility, permeability, and bioavailability without surfactants, enabling higher drug concentrations at tumor sites and reducing toxicity.
- These NPs can be engineered for slow drug release, which improves therapy effectiveness and reduces the need for frequent dosing.
- Targeting overexpressed folate receptors (FRs) on certain cancer cells with folate-modified chitosan NPs can improve treatment outcomes and predict therapy success, while also enhancing the oral absorption of poorly soluble drugs.
A low-dose pemetrexed-cisplatin combination regimen induces significant nephrotoxicity in mice.
BMC Nephrol
October 2024
Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
Article Synopsis
- Pemetrexed combined with cisplatin is used for cancer treatment, but its effects on kidney toxicity were unclear, prompting a study using mice to investigate kidney injury from these drugs alone and in combination.
- Mice were divided into four groups and treated with either captisol, pemetrexed, cisplatin, or both drugs together, after which kidney function was assessed through glomerular filtration rate and necropsy.
- The results showed that the combination treatment significantly increased kidney damage and biomarkers of injury compared to individual treatments, suggesting increased nephrotoxicity when pemetrexed is combined with cisplatin, even at non-lethal doses.
Proximity Ligation Assay for the Analysis of Iron-Mediated Protein-Protein Interactions in the Nucleus.
Methods Mol Biol
July 2024
Genetics and Metabolism Section, Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Iron forms essential cofactors used by many nuclear enzymes involved in genome maintenance. However, unchaperoned nuclear iron may represent a threat to the surrounding genetic material as it promotes redox toxicity that may affect DNA integrity. Safely handling intracellular iron implies metal transfer and cofactor assembly processes based on protein-protein interactions.
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